β-thujaplicin (CAS# 499-44-5)

Ipropati yeMichiza:

Ifomula yeemolekyuli	C10H12O2
IMisa yeMolar	164.2
Ukuxinana	1.0041 (uqikelelo olurhabaxa)
Indawo yokunyibilika	50-52°C(lit.)
Indawo yeBoling	140°C10mm Hg(lit.)
Indawo yokuflasha	128.1°C
Ukunyibilika	Ayinyibiliki emanzini
Uxinzelelo loMphunga	8.98E-05mmHg ku-25°C
Imbonakalo	Ezingenambala, iikristale zeprismatic (ziphinde zenziwe kwakhona kwi-ethanol ye-anhydrous)
Umbala	Mhlophe
Merck	14,9390
pKa	7.06±0.30(Kuqikelelwe)
Imeko yoGcino	Itywinwe kwindawo eyomileyo, yoBubushushu beGumbi
Uzinzo	Izinzile unyaka om-1 ukusuka kumhla wokuthenga njengoko kunikezelwe. Izisombululo kwi-DMSO okanye i-ethanol inokugcinwa kwi--20 ° ukuya kwiinyanga ezi-4.
Inovakalelo	Kuphephe ukudibana neeoksidi
Refractive Index	1.5190 (uqikelelo)
MDL	MFCD00059582
Isifundo se-in vitro	Kwi-U87MG kunye ne-T98G imigca yeseli ye-glioma, i-hinokitiol ibonisa ukuhla kwe-dose exhomekeke kwi-viability, kunye ne-IC 50 ixabiso le-316.5 ± 35.5 kunye ne-152.5 ± 25.3 µM, ngokulandelanayo. I-Hinokitiol icinezela umsebenzi we-ALDH kunye nokukwazi ukuzihlaziya kwiiseli ze-glioma stem, kwaye inqanda i-vitro oncogenicity. I-Hinokitiol iphinda inciphise ukubonakaliswa kwe-Nrf2 kwiiseli ze-glioma ngendlela exhomekeke kwidosi. I-Hinokitiol (0-100 μM) inqanda ukukhula kweeseli zomhlaza wekoloni kwi-dose- kunye nexesha elixhomekeke kwixesha. I-Hinokitiol (5, 10 μM) iyancipha i-DNMT1 kunye ne-UHRF1 mRNA kunye nokubonakaliswa kweprotheni, kwaye yandisa intetho ye-TET1 ngokuphucula izinga le-5hmC kwiiseli ze-HCT-116. Ngaphezu koko, i-hinokitiol inciphisa isimo se-methylation kwaye ibuyisela i-mRNA intetho ye-MGMT, i-CHST10, kunye ne-BTG4 izakhi zofuzo.

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Iimpawu ezinobungozi	Xn – Iyingozi
Iikhowudi zoMngcipheko	22 – Iyingozi xa iginyiwe
Inkcazelo yoKhuseleko	36 – Nxiba iimpahla ezifanelekileyo zokukhusela.
WGK eJamani	3
RTECS	GU4200000

Intshayelelo

I-Hinokiol, ekwabizwa ngokuba yi-α-terpene alcohol okanye i-Thujanol, yi-organic compound yendalo eyenye yamacandelo e-turpentine. I-Hinoylol lulwelo olungenambala, olucacileyo kunye nencasa enuka kamnandi yepine.

I-Hinokiol ineendlela ezahlukeneyo zokusetyenziswa. Isetyenziswa ngokubanzi kwishishini le-perfume kunye ne-fragrance ukongeza ivumba kunye nevumba kwiimveliso. Okwesibini, utywala bejuniper bukwasetyenziswa njenge fungicide kunye nepreservative, kwaye ihlala isetyenziswa ekulungiseleleni izibulali ntsholongwane kunye nefungicides.

Kukho iindlela ezininzi zokulungiselela ijuniperol. Ngokuqhelekileyo, inokuthi ikhutshwe nge-distillation yeoli eguquguqukayo ukusuka kumagqabi omjunipha okanye ezinye izityalo ze-cypress, kwaye zihlulwe kwaye zihlanjululwe ukufumana ijuniperol. I-alcohol ye-Hinoki nayo inokudityaniswa nge-chemical synthesis.

Ulwazi lokhuseleko lwejuniperol: Ayinatyhefu kwaye ibonwa njengekhuselekile. Njenge-organic compound, kusafuneka iphathwe kwaye igcinwe ngokuchanekileyo. Kuphephe ukudibana nesikhumba kunye namehlo, kwaye uhlambulule ngokukhawuleza ngamanzi xa udibana nengozi. Kufuneka igcinwe kude namadangatye avulekileyo kunye namaqondo obushushu aphezulu, kwaye igcinwe kwindawo epholileyo, eyomileyo.

Ngaphambili: Z-ASP-OBZL(CAS# 4779-31-1)

Okulandelayo: 3-(Trifluoromethoxy)benzyl bromide (CAS# 50824-05-0)

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