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2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0) Umfanekiso obonakalayo
  • 2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0) 1

2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0)

Ipropati yeMichiza:

Ifomula yeemolekyuli I-C5H4Cl2N2
IMisa yeMolar 163
Ukuxinana 1.39 g/mL ku-25 °C (lit.)
Indawo yokunyibilika 26-28 °C (lit.)
Indawo yeBoling 108-109 °C/11 mmHg (ilayiti.)
Indawo yokuflasha >230°F
Ukunyibilika Inyibilika kwi-chloroform, ether, ethyl acetate kunye ne-toluene
Uxinzelelo loMphunga 0.079mmHg ku-25°C
Imbonakalo umgubo kwintlama ukusula ulwelo
Umbala Mhlophe okanye AyinaMbala ukuya Phantse mhlophe okanye Phantse ayinambala
pKa -2.44±0.29(Kuxelwe kwangaphambili)
Imeko yoGcino Umoya ongaphakathi,2-8°C

Iinkcukacha zeMveliso

Iithegi zeMveliso

Umngcipheko kunye noKhuseleko

Iimpawu ezinobungozi C – Iyadleka
Iikhowudi zoMngcipheko 34 – Ibangela ukutsha
Inkcazelo yoKhuseleko S26 – Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango.
S36/37/39 – Nxiba iimpahla ezifanelekileyo zokukhusela, iiglavu kunye nokukhusela amehlo/ubuso.
S45 - Kwimeko yengozi okanye ukuba uziva ungaphilanga, funa iingcebiso zonyango ngokukhawuleza (bonisa ileyibhile nanini na kunokwenzeka.)
S27 – Khulula ngoko nangoko zonke iimpahla ezosulelekileyo.
Izazisi ze-UN UN 3261 8/PG 2
WGK eJamani 3
I-TSCA Ewe
Ikhowudi ye-HS 29335990
IKlasi yeeNgozi 8
Iqela lokuPakisha III

2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0) Ulwazi

Sebenzisa I-2, i-4-dichloro-5-methylpyrimidine ingasetyenziselwa ukulungiswa kwe-2-fluoro-5-trifluoromethylpyrimidine. I-2-fluoro-5-trifluoromethylpyrimidine yinto ebalulekileyo ephakathi kwi-syntheuticals yamachiza, enokusetyenziswa ukwenza i-dihydrofuran edibeneyo ye-ring compounds, kunye ne-dihydrofuran edibeneyo ye-dihydrofuran i-compounds ingasetyenziswa njenge-protein ye-G edibene ne-receptor ye-GPR119 modulators, kunyango lwesifo seswekile, ukutyeba kakhulu kunye nesifo se-dyslipidemia. Ukongeza, i-2-fluoro-5-trifluoromethylpyrimidine ingasetyenziselwa njengendawo ephakathi kwi-synthesis yamachiza kunyango lwe-Alzheimer's disease kunye ne-schizophrenia.
ukulungiselela I-5-methyluracil 75g (0.59mol), i-phosphorus oxychloride 236g, i-triethylamine hydrochloride 16.5g (0.12mol), yongezwa kwi-flask yokusabela, ishushu kwi-100 ℃ ~ 110 ℃, i-Reflux reaction 5H, i-phosphorus ℃ ℃ ipholile kwi-penta 248(1.19mol), ukusabela kokugcina ubushushu 2H. Emva kokugqitywa kwempendulo, i-phosphorus oxychloride yafunyanwa nge-distillation phantsi koxinzelelo oluncitshisiweyo, kwaye i-distillation phantsi koxinzelelo oluncitshisiweyo yaqhubeka ifumana i-88g (0.54mol) ye-2, 4-dichloro-5-methylpyrimidine kwisivuno se-91.5%.
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