2 4-Difluorobenzoic acid (CAS# 1583-58-0)

Isicelo

2, 4-difluorobenzoic acid lichiza elibalulekileyo kunye ne-pesticide ephakathi, njenge-2, 4-difluorobenzoic acid isetyenziselwa ukudibanisa iziyobisi ze-antifungal fluconazole, i-voriconazole kunye ne-pesticide ephakathi kwe-4-fluorosalicylic acid, i-intermediate ye-3, i-5-difluoro, njl. .2, 4-difluorobenzoic acid nazo zisetyenziswe kwizinto zekristale elulwelo, ezinenzuzo zexabiso eliphezulu kunye nethemba elihle lemarike.

Ukulungiselela

Yongeza i-2, i-4-dinitrotoluene kunye namanzi kwisitya sokuphendula, lungisa ixabiso le-pH kwi-7, ugxobhoze kwaye ushushu kwi-75 ° C. I-potassium permanganate, i-magnesium sulfate kunye ne-phase transfer catalyst yongezwa kwiibhetshi. Emva kokongeza, qhubeka uvuselela kwaye uphendule kwiqondo lokushisa rhoqo kwiiyure ezi-3. Hlunga ngelixa ushushu kwaye uhlambe ikeyiki yokucoca ngamanzi ashushu. Hlanganisa i-filtrate, i-acidify kunye ne-35% ye-hydrochloric acid ukuya kwi-pH 2-3, kukho inani elikhulu le-precipitates emhlophe emva kokuba iikristale zihlanjululwe ngokupheleleyo, zihluzwe, zihlanjwe, ziphinde zomiswe ukuze zifumane iikristale ezimhlophe njenge-2,4-dinitrobenzoic acid. . Umlinganiselo we-2, 4-dinitrotoluene ukuya kwi-potassium permanganate ngu-2.4: 1. Imveliso yemveliso yeli nyathelo yi-90.7%.

yongeza i-N, N-dimethylmethylphthalamide kwi-container reaction, ukushisa kwi-100 ~ 110 ℃, i-preheat ye-0.5 ~ 1h. Yongeza i-anhydrous potassium fluoride eyomileyo phantsi kokuvuselela kwaye ugcine ukushisa kwangaphambili kwi-0.5-1h. Emva koko, i-2, i-4-dinitrobenzoic acid kunye ne-hexyltrimethylammonium bromide yongezwa ngokukhawuleza kwisitya sokuphendula ngexesha elinye, kwaye ukufudumeza kwaqhubeka ukuya kwi-120 ℃, ukushisa kwagcinwa kwaye ukusabela okuchukumisayo kwaqhubeka. Emva kwe-7h ye-reflux reaction, i-solvent ifunyanwa nge-distillation, kwaye emva koko i-reaction liquid ihlanjululwa ngomphunga. Iqhekeza eliqokelelweyo li-emulsion emhlophe. Emva kokuma ixesha elithile, iqhezu elijoliswe kwi-oyile litshona ukuya ezantsi, ulwelo olumhlophe olucacileyo kwindawo ephezulu luyagalelwa, kwaye ioli iyaphola ukuze ikhuphe iikristale ezimhlophe ukufumana imveliso ekrwada; imveliso ekrwada iphinda ihlaziywe, iSuction filtration, ukuhlamba, kunye nokomisa ukufumana iicrystals ezimhlophe ze-2,4-difluorobenzoic acid. Umlinganiselo we-2, 4-dinitrobenzoic acid kwi-potassium fluoride ngu-2.7: 1. Imveliso yemveliso yeli nyathelo yi-72.4%.

Intshayelelo
I-2,4-Difluorobenzoic acid yi-organic compound. Oku kulandelayo kukwazisa kwiipropati, ukusetyenziswa, iindlela zokulungiselela kunye nolwazi lokhuseleko lwe-2,4-difluorobenzoic acid:

Umgangatho:
- Imbonakalo: I-2,4-Difluorobenzoic acid iyikristale emhlophe eqinileyo.
- Ukunyibilika: Inyibilika kwizinyibilikisi eziqhelekileyo ze-organic ezifana ne-ethanol, i-methanol kunye ne-methylene chloride.

Sebenzisa:
- Izinto ezibonakalayo ezibonakalayo: Inokusetyenziswa njengenye yezinto ezisetyenziselwa ukulungiswa kwezinto ezibonakalayo kunye neefilimu ezibonakalayo.
- Izicelo zoshishino: I-2,4-difluorobenzoic acid ingasetyenziselwa kwishishini le-electronics, i-coatings kunye ne-plastics industry kunye ne-anti-corrosion, i-anti-oxidation kunye ne-anti-ultraviolet effects.

Indlela:
- 2,4-Difluorobenzoic acid inokufumaneka nge-fluorination ye-hydrofluoric acid kunye ne-p-methylanisole.

Ulwazi ngoKhuseleko:
- Xa usebenza, uthuli kufuneka lugwenywe ukuphepha ukuphefumla kunye nokudibana kwamehlo. Kwangaxeshanye, iimeko ezifanelekileyo zokungenisa umoya kufuneka zigcinwe.
- Kulumkele ukudibana neearhente ezinamandla ze-oxidizing okanye iiasidi ezinamandla ukuphepha ukuphendula okuyingozi