2-Chloro-3-fluoro-6-picoline (CAS# 374633-32-6)

Intshayelelo

Imbonakalo: Ngokuqhelekileyo ayinambala ukuya kulwelo olukhanyayo olutyheli, le mpawu yembonakalo ithetha ukuba inobuntununtunu kukukhanya kunye nobushushu, kwaye kuyafuneka ukuba kuthathwe amanyathelo okuthintela ukukhanya kunye nolawulo lobushushu ngexesha lokugcinwa kunye nokuthutha, njengokusebenzisa iibhotile zeglasi ezimdaka kunye nokuzigcina. kwindawo yokugcina impahla epholileyo ukuthintela ukuba umbala ube nzulu ngakumbi kunye nokonakala.

I-Solubility: I-compound ine-solubility efanelekileyo kwii-solvents eziqhelekileyo ze-organic, ezifana ne-toluene kunye ne-dichloromethane, ilandela umgaqo we-solubility efanayo, kwaye inobudlelwane kunye ne-solvents yezinto eziphilayo ngenxa yenxalenye ye-hydrophobic ye-molecule; Nangona kunjalo, i-solubility emanzini iphantsi, kwaye i-hydrogen bonding eyomeleleyo phakathi kweamolekyu zamanzi kunzima ukuphulwa ngokufanelekileyo yi-molecule, okwenza kube nzima ukuyisasaza.
Indawo yokubilisa kunye noxinaniso: Idatha yendawo yokubilisa inxulumene ngokusondeleyo nokuguquguquka kwayo kwaye inokubonelela ngemilinganiselo engundoqo kwimisebenzi efana ne-distillation kunye nokucoca, kodwa ngelishwa ixabiso lendawo yokubilisa ayichazwanga ngokubanzi. Ubuninzi bayo buphezulu kancinane kunobo bamanzi, kwaye ukuqonda ukuxinana kunganceda ukuqikelela ngokuchanekileyo ubudlelwane boguqulo lobuninzi bomthamo kwimisebenzi yovavanyo okanye iinkqubo zefektri ezinjengokhutshelo lolwelo kunye nemitha echanekileyo.
Iimpawu zeMichiza
Impendulo yokutshintsha: Iathom yeklorine kunye neathom yefluorine kwimolekyuli zezona ndawo zinokuthi zisebenze. Kwi-reaction ye-nucleophilic substitution, i-nucleophiles enamandla inokuhlasela iindawo apho i-chlorine kunye ne-athomu ye-fluorine ikhona, ithathe indawo ye-athomu ehambelanayo, kwaye ivelise i-pyridine derivatives entsha. Ngokomzekelo, idibaniswe kunye ne-nucleophiles equkethe i-nitrogen kunye ne-sulfur-containing ukuphuhlisa uluhlu lwe-nitrogen-containing heterocyclic compounds kunye nezakhiwo ezinzima kakhulu zokufumana iziyobisi okanye ukuhlanganiswa kwezinto.
Ukusabela kwe-Redox: i-pyridine ring ngokwayo izinzile, kodwa xa i-oxidants eqinile, njenge-potassium permanganate kunye ne-hydrogen peroxide idibaniswe neemeko ze-acidic, i-oxidation ingenzeka, okubangelwa ukutshatyalaliswa okanye ukuguqulwa kwesakhiwo se-pyridine ring; Ngokwahlukileyo, kunye ne-agent yokunciphisa efanelekileyo, efana ne-metal hydrides, inokwenzeka ithiyori kwi-hydrogenation ye-intramolecular unsaturated bonds.
Okwesine, indlela yokudibanisa
Indlela eqhelekileyo yokudibanisa kukuqala ukusuka kwizinto ezilula zepyridine kwaye ngokuthe ngcembe wakhe isakhiwo esijoliswe kuyo ngokusebenzisa i-halogenation kunye ne-fluorination reactions. Izixhobo zokuqala ze-pyridine ziqala ngokukhetha i-methylated kwaye amaqela e-methyl aziswa ngexesha elifanayo; Emva koko sebenzisa i-halogenation reagents, njenge-chlorine kunye ne-chlorine yamanzi, kunye ne-catalysts efanelekileyo kunye neemeko zokuphendula, ukuphumeza ukuqaliswa kwee-athomu ze-chlorine; Ekugqibeleni, ii-reagents ze-fluorinated, ezifana ne-Selectfluor, zisetyenziselwa ngokuchanekileyo i-fluorinate indawo ekujoliswe kuyo ukufumana i-2-chloro-3-fluoro-6-methylpyridine.
Usebenzisa
I-Drug synthesis intermediates: isakhiwo salo esisodwa siyathandwa ngamachiza amayeza, kwaye siphakathi komgangatho ophezulu wokuphuhliswa kwamachiza amatsha okulwa ne-antibacterial, antiviral, kunye ne-antitumor. Iimpawu ze-elektroniki kunye nesakhiwo sendawo yamakhonkco e-pyridine kunye neendawo zabo ezinokuthi zibophe ngokuthe ngqo kwiiprotheni ezijoliswe kuyo kwi-vivo, kwaye kulindeleke ukuba ziguqulwe zibe izithako ezisebenzayo kunye nokusebenza kakuhle emva kokuguqulwa kwamanyathelo amaninzi.
Isayensi yezinto: Kwinkalo ye-organic material synthesis, ingasetyenziselwa ukuvelisa izinto ezisebenzayo zepolymer, izinto ze-fluorescent, njl., ngenxa yokukwazi kwayo ukwazisa ngokuchanekileyo i-chlorine, i-athomu ye-fluorine kunye nezakhiwo ze-pyridine, izixhobo ezikhethekileyo zombane kunye ne-optical. iipropathi, kunye nokukhuthaza uphuhliso lwetekhnoloji ye-cutting-edge efana nemathiriyeli ehlakaniphile kunye nemathiriyeli yokubonisa.