2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine(CAS#865363-93-5)
Ukwazisa i-2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine (CAS:865363-93-5), i-groundbreaking nucleoside analog emiselwe ukuguqula intsimi yebhayoloji ye-molecular kunye nophando lwamachiza. Le khompawundi entsha yenzelwe ukukhulisa ukuqonda konxibelelwano lwe-nucleic acid kunye neenkqubo zeselula, iyenza ibe sisixhobo esixabisekileyo kubaphandi nakwizazinzulu ngokufanayo.
I-2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine ibonakaliswe ngokuguqulwa kwayo okukhethekileyo kwesakhiwo, okubandakanya i-ethynyl kunye ne-fluorine substitutions kwi-4 kunye ne-2 'izikhundla, ngokulandelanayo. Olu hlengahlengiso aluphuculi nje kuphela uzinzo lwekhompawundi kunye nokufumaneka kwebhayoloji kodwa lukwaphucula amandla ayo okungena kwiinwebu zeselula, ukuvumela unikezelo olusebenzayo ngakumbi kunye nokuthathwa kwiinkqubo ezahlukeneyo zebhayoloji.
Le analog ye-nucleoside ibonise amandla athembisayo kwizicelo ezahlukeneyo, kubandakanywa uphando lwe-antiviral kunye ne-anticancer. Ukukwazi kwayo ukulinganisa ii-nucleosides zendalo ngelixa ibonisa iimpawu ze-biochemical ezahlukileyo ziyenza ibe ngumgqatswa ofanelekileyo kuphuhliso lwee-agent zonyango zonyango. Abaphandi banokusebenzisa i-2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine ukufunda i-RNA kunye ne-DNA synthesis, ukuphanda ukusebenzisana kwe-enzyme, kunye nokuphonononga iindlela zokusebenza kwamachiza akhoyo.
Ukongeza kwizicelo zayo zophando, le khompawundi ikulungele ukudlala indima ebalulekileyo kuphuhliso lwesizukulwana esilandelayo sonyango. Ngokubonelela ngolwazi malunga nokuziphatha kwe-nucleic acid kunye nokusebenzisana, i-2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine inokunceda ekuqulunqweni konyango olusebenzayo kunye nokujoliswe kuyo kwizifo ezahlukeneyo.
Isishwankathelo, i-2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine (CAS:865363-93-5) yi-cutting-edge nucleoside analog enika amathuba angenakulinganiswa nanto ophando kunye nophuhliso kwi-molecular biology kunye ne-pharmacology. Yamkela ikamva lokufunyaniswa kwenzululwazi ngale khompawundi ikhethekileyo kwaye uvule amathuba amatsha kwiinzame zakho zophando.
