I-2,4,5-Trifluorophenylacetic Acid (CAS# 209995-38-0)
Isicelo
2,4, 5-trifluorophenylacetic acid sisiqina esimhlophe esisetyenziselwa ukudibanisa ichiza elitsha le-sitagliptin intermediates kunyango lwe-type II yeswekile. I-sitagliptin yi-inhibitor yokuqala ye-DPP-IV esandula ukudweliswa ngu-Merck. Inesiphumo esihle sokunyanga, iziphumo ebezingalindelekanga ezincinci, ukhuseleko olulungileyo kunye nokunyamezelana kunyango lwesifo seswekile sohlobo lwe-II, kwaye inethemba elibanzi lemarike.
Inkcazo
Imbonakalo yeCrystallization
Umbala oMhlophe ukuya kuMhlophe
pKa 3.78±0.10(Kuqikelelwe)
Imeko yoGcino Itywinwe kwindawo eyomileyo, kuBubushushu beGumbi
Refractive Index 1.488
Ukhuseleko
Iimpawu zeHazard Xi - Irritant
Iyacaphukisa
Iikhowudi zoMngcipheko R37/38 - Ukucaphukisa kwinkqubo yokuphefumla kunye nolusu.
R41 - Umngcipheko womonakalo omkhulu emehlweni
Inkcazo yoKhuseleko S26 - Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango.
S39 -Nxiba ukhuseleko lwamehlo / ubuso.
WGK eJamani 3
Ikhowudi yeHS 29163990
I-Hazard Class IRRITANT
Ukupakisha kunye noGcino
Ipakishwe kwi-25kg / 50kg igubu. Gcina kwindawo emnyama, itywinwe kwindawo eyomileyo, ubushushu beGumbi
Intshayelelo
Ukwazisa i-2,4,5-Trifluorophenylacetic Acid, isisindi esimhlophe esisetyenziswa ngokubanzi kwishishini lamachiza ukudibanisa i-sitagliptin intermediates kunyango lwe-type II yeswekile.
Njengenxalenye ebalulekileyo ekuvelisweni kwe-sitagliptin, i-2,4,5-Trifluorophenylacetic Acid idlale indima ebalulekileyo ekuphuhliseni eli chiza lisebenza kakhulu. I-Sitagliptin yi-DPP-IV inhibitor yamva nje edweliswe kutshanje nguMerck. Iqhayisa ngeziphumo ezigqwesileyo zokunyanga, iziphumo ebezingalindelekanga ezincinci, ukhuseleko kunye nokunyamezelana, kwaye iye yaba lichiza lokuya kunyango lwesifo seswekile sohlobo lwe-II.
Olunye uncedo oluphambili lwe-2,4,5-Trifluorophenylacetic Acid kukuba yenza ukuveliswa kwe-sitagliptin ngexabiso eliphantsi, nto leyo evumela abantu abaninzi ukuba babe nofikelelo kula mayeza atshintsha ubomi. Ukongeza, iyasebenza kakhulu kunyango lwesifo seswekile kwaye ibonelela ngethemba elitsha kwabo balwa nale meko.
Ukubonakala kwe-2,4,5-Trifluorophenylacetic Acid i-crystalline emhlophe kumgubo omhlophe, okwenza kube lula ukuchonga, ukuphatha kunye nokuthutha. Kananjalo izinzile ngokwentelekiso phantsi kweemeko eziqhelekileyo, okuthetha ukuba inokugcinwa ixesha elide ngaphandle kokuthotywa.
I-2,4,5-Trifluorophenylacetic Acid ininzi kakhulu kwaye ingasetyenziselwa ukuhlanganiswa kwezinye iikhompawundi eziyinkimbinkimbi ngaphaya kwe-sitagliptin intermediates. Inemisebenzi eyahlukeneyo yemizi-mveliso, kubandakanya ukuveliswa kweekhemikhali zezolimo, iirasi, kunye neziphakathi. Isenokusetyenziswa njengesixhobo sokuqala sokwenziwa koluhlu olubanzi lweeamolekyu ezinezicelo ezahlukeneyo.
Kwinkampani yethu, siyazingca ngokubonelela nge-Acid ekumgangatho ophezulu we-2,4,5-Trifluorophenylacetic kubathengi bethu. Imveliso yethu ihlangabezana neyona migangatho iphezulu yomgangatho kwaye yenziwa ngokulandela izikhokelo ezingqongqo ukuqinisekisa ukuhambelana kunye nokucoceka.
Ukuqukumbela, i-2,4,5-Trifluorophenylacetic Acid iyikhompawundi eluncedo kakhulu eye yaba yinto ebalulekileyo ekuveliseni i-sitagliptin, iyeza lokuqala lohlobo lwe-II yeswekile. Ukuguquguquka kwayo kunye nokusebenza kwayo kuyenza ibe yi-asethi exabisekileyo kumashishini amayeza kunye neekhemikhali, kwaye sinebhongo ngokunikezela ngomgangatho ophezulu we-2,4,5-Trifluorophenylacetic Acid kubathengi bethu.
