4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile（CAS# 189956-45-4)

Ifomula yeemolekyuli	I-C11H8N4O
IMisa yeMolar	212.21
Ukuxinana	1.31±0.1 g/cm3(Kuxelwe kwangaphambili)
Indawo yokunyibilika	> 300°C
Indawo yeBoling	399.7 ° C kwi-760 mmHg
Indawo yokuflasha	195.6°C
Ukunyibilika	I-DMSO (Kancinci), iMethanol (Kancinci)
Uxinzelelo loMphunga	0-0Pa kwi-20-25℃
Imbonakalo	Iqinile
Umbala	UPale Brown ukuya kuBrown
pKa	8.66±0.40(Kuqikelelwe)
Imeko yoGcino	2-8°C
Refractive Index	1.67

Iinkcukacha zeMveliso

LogP	0.9 kwi-pH6.6
sebenzisa	I-4 - [(4-hydroxy-2-pyrimidinyl) i-amino] i-benzonitrile ingasetyenziselwa njengento ephakathi kwi-organic synthesis kunye ne-pharmaceutical intermediate, kwaye ingasetyenziselwa kwi-laboratory ye-Organic synthesis process kunye nekhemikhali kunye nophando lwamachiza kunye nenkqubo yophuhliso.
ukulungiselela	ubunzima be-2-(methylthio) pyrimidine -4 (3H)-enye (3g,21mmol) kunye ne-4-aminobenzonitrile (2.99g,25mmol) kwi-flask ephantsi ye-50mL ejikelezayo, ekhuselwe yi-nitrogen, ishushu ngokukhawuleza kwi-180 ℃, kwaye iphendule i-8 iiyure. Emva kokuba i-reaction ipholile, i-20mL ye-acetonitrile yongezwa kunyango lwe-ultrasonic, ukuhluzwa, ikhekhe lokucoca lihlanjwe nge-acetonitrile, akukho ntsalela ye-4-aminobenzonitrile ifunyenwe yi-TLC, kunye ne-yellow yellow solid solid efunyenwe ngokumisa ikhekhe lokucoca yi-4-( (4-oxo -1, 6-dihydropyrimidine -2-yl) amino) benzonitrile ene isivuno sama-73.6%.