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I-4-Bromo-3-fluorobenzoic acid (CAS# 153556-42-4) Umfanekiso obonakalayo
  • I-4-Bromo-3-fluorobenzoic acid (CAS # 153556-42-4) 1

I-4-Bromo-3-fluorobenzoic acid (CAS# 153556-42-4)

Ipropati yeMichiza:

Ifomula yeemolekyuli C7H4BrFO2
IMisa yeMolar 219.01
Ukuxinana 1.789±0.06 g/cm3(Kuxelwe kwangaphambili)
Indawo yokunyibilika 207 °C
Indawo yeBoling 296.1±25.0 °C(Kuqikelelwe)
Indawo yokuflasha 132.9°C
Uxinzelelo loMphunga 0.000663mmHg ku-25°C
pKa 3.63±0.10(Kuqikelelwe)
Imeko yoGcino Itywinwe kwindawo eyomileyo, yoBubushushu beGumbi

Iinkcukacha zeMveliso

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Ulwazi lweReference

Usebenzisa I-4-bromo-3-fluorobenzoic acid yinto ebalulekileyo yekhemikhali ekrwada engasetyenziselwa ukulungiselela iintlobo ezahlukeneyo zeziyobisi (ezifana ne-anti-cancer drug benzamit).
Indlela yokudibanisa I-4-bromo-3-fluorobenzoic acid inokufumaneka nge-oxidation ye-4-bromo-3-fluorotoluene nge-potassium permanganate.
(1) i-oxidation: i-100kg ye-kg4-bromo -3-fluorotoluene, i-120kg yamanzi kunye ne-0.1kg ye-alcohol enamafutha e-polyether sodium sulfate (AES) yongezwa ngokulandelelana kwi-kettle ye-K-400L ye-glass-lined reaction (eyenziwe yi-Jiangsu industrial lining chemicals). izixhobo co., ltd.) ngokushukumisa kunye nokufudumeza kunye nesixhobo reflux condensation, ngoko I-167kg ye-potassium permanganate yongezwa ngokucothayo phantsi kwemeko evuselelayo, igcinwe kwindawo ebilayo, kwaye iphendule iiyure ezili-9, yeka ukusabela emva kokuba isisombululo se-reflux singasenawo amaso e-oyile;
2
(3) Susa i-potassium permanganate: Ukuze kususwe i-potassium permanganate eseleyo kwi-filtrate, i-0.1kg ye-sodium sulfite kufuneka ifakwe kwi-filtrate efunyenwe kwinqanaba (2), isixa esongezelelweyo se-sodium sulfite sisekelwe kulwelo olucacileyo kunye umbala omfusa wesisombululo.
(4) i-acidification: kwisimo esichukumisayo, ngokukhawuleza yongeza i-substance kwisisombululo esifunyenwe kwisinyathelo (3) kunye noxinzelelo lwe-12mol / L concentrated hydrochloric acid. xa ixabiso le-pH lesisombululo li-2.2, yeka ukongeza i-hydrochloric acid egxininisiweyo kwaye uqhubeke nokusabela kwi-30min.
(5) i-crystallization: kwimeko ephazamisayo, isisombululo esifunyenwe kwisinyathelo (4) sipholile ukuya kwi-2 ° C, kunye ne-crystals ehlanjululwe kwisisombululo yi-4-bromo-3-fluorobenzoic acid. Ngethuba lokusebenza, kufuneka iqhutywe ngokuqhubekayo, ngaphandle koko i-4-bromo-3-fluorobenzoic acid iya kwenza i-slide enkulu, okunzima ukujongana nayo kwiinkqubo ezilandelayo;
(6) Ukuhluzwa kunye nokuhlamba: Ulwelo oluxutyiweyo oluqulathe iikristale zeasidi ezi-4-bromo-3-fluorobenzoic ezifunyenwe kwinyathelo (5) lugxininiswe ukuze kufumaneke ikeyiki yokucoca eyimveliso yeasidi eyi-4-bromo-3-fluorobenzoic ekrwada, imveliso ekrwada. ihlanjwe ngamanzi acocekileyo kunye ne-centrifuged (usebenzisa i-centrifuge enomsebenzi wokuvasa) ukufumana ephuculweyo. 4-bromo-3-fluorobenzoic acid;
(7) Ukomisa: I-4-bromo-3-fluorobenzoic acid eqinileyo elungiselelwe kwinqanaba (6) yomiswe kwi-75 ° C kwiiyure ze-12 ukufumana i-197 kg4-bromo-3-fluorobenzoic acid, umxholo wayo ungaphezulu kwe-98 %.
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