5-Bromo-3-nitro-2-pyridinol (CAS# 15862-34-7)
Umngcipheko kunye noKhuseleko
| Iikhowudi zoMngcipheko | I-R22 – Iyingozi xa iginyiwe I-R37/38 – Iyacaphukisa inkqubo yokuphefumla kunye nolusu. I-R41 – Umngcipheko womonakalo omkhulu emehlweni R36/37/38 – Ukucaphuka kwamehlo, inkqubo yokuphefumla kunye nolusu. I-R20 – Inobungozi ngokuphefumla |
| Inkcazelo yoKhuseleko | S26 – Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango. S36/37/39 – Nxiba iimpahla ezifanelekileyo zokukhusela, iiglavu kunye nokukhusela amehlo/ubuso. S36 – Nxiba iimpahla ezifanelekileyo ezikhuselayo. |
| Izazisi ze-UN | 2811 |
| WGK eJamani | 3 |
| Ikhowudi ye-HS | 29337900 |
| Inqaku Lengozi | Inobungozi |
| IKlasi yeeNgozi | OKUTHUMEKAYO |
Ulwazi lweReference
| Sebenzisa | I-5-bromo-2-hydroxy-3-nitropyridine yi-organic intermediate engasetyenziselwa ukulungisa iikhompawundi 3-amino-1- (2-oxo-2- (3 '-(trifluoromethyl)-[1,1'-biphenyl ]-4-yl) ethyl)-5-(pyrrole i-alkyl-1-yl-sulfonyl) i-pyridin-2 (1H) -enye, le ngqungquthela yi-DOCK1 ye-inhibitory compound. |
| indlela yokuhlanganisa | i-nitric acid (60-61%,3.5mL) yongezwa kwisisombululo (10mL) ye-5-bromopyridine -2 (1H) -enye (1.75g, 10.1mmol) kwi-asidi ye-sulfuric kwi-0 ℃. Umxube uvunyelwe ukuba ushushu kwiqondo lokushisa kwaye uqhube iiyure ezi-3. Umxube wokusabela ugalelwa emanzini e-ice kwaye i-precipitate ebangelwayo iqokelelwa ngokuhluzwa. Imveliso efunyenweyo yahlanjwa ngamanzi kwaye yomiswa kwi-vacuum, inika i-5-bromo-2-hydroxy-3-nitropyridine (i-960mg, i-43% isivuno) njengento eqinile emhlophe. 1H NMR(500MHz,CDCl3)δ:8.57(s,1H),8.26(s,1H). |
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