5-Fluorocytosine (CAS# 2022-85-7)
Umngcipheko kunye noKhuseleko
| Iikhowudi zoMngcipheko | R40 – Ubungqina obuncinane besiphumo somhlaza R36/37/38 – Ukucaphuka kwamehlo, inkqubo yokuphefumla kunye nolusu. I-R63 – Ingozi enokwenzeka yokwenzakala kumntwana ongekazalwa |
| Inkcazelo yoKhuseleko | S22 – Musa ukuphefumla uthuli. S24/25-Kuphephe ukudibana nolusu namehlo. S45 - Kwimeko yengozi okanye ukuba uziva ungaphilanga, funa iingcebiso zonyango ngokukhawuleza (bonisa ileyibhile nanini na kunokwenzeka.) S36/37 – Nxiba iimpahla ezifanelekileyo zokukhusela kunye neeglavu. S36/37/39 – Nxiba iimpahla ezifanelekileyo zokukhusela, iiglavu kunye nokukhusela amehlo/ubuso. S27 – Khulula ngoko nangoko zonke iimpahla ezosulelekileyo. S26 – Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango. |
| WGK eJamani | 2 |
| RTECS | HA6040000 |
| FLUKA BRAND F IIKHOWUDI | 10-23 |
| Ikhowudi ye-HS | 29335990 |
| Inqaku Lengozi | Ityhefu/Inovakalelo kuKhanya |
| IKlasi yeeNgozi | I-YATHUMILE, IYABONA UKUKHANYA |
| Ubutyhefu | I-LD50 kwiigundane (mg / kg):> 2000 ngomlomo kunye ne-sc; 1190 ip; 500 iv (Grunberg, 1963) |
5-Fluorocytosine (CAS# 2022-85-7) Intshayelelo
umgangatho
Le mveliso ngumgubo wekristale omhlophe okanye ongekho mhlophe, awunavumba okanye unevumba elincinane. I-solubility kancinane emanzini, i-solubility ye-1.2% kwi-20 °C emanzini, i-soluble kancinane kwi-ethanol; Iphantse inganyibiliki kwi-chloroform kunye ne-ether; Inyibilika kwi-dilute hydrochloric acid okanye isisombululo sesodium hydroxide. Izinzile kwiqondo lokushisa, i-crystals iyancipha xa ibanda, kwaye inxalenye encinci iguqulwa ibe yi-5-fluorouracil xa ishushu.
Le mveliso lichiza le-antifungal lenziwe ngo-1957 kwaye lisetyenziswe kwiklinikhi ngo-1969, kunye nesiphumo esicacileyo se-antibacterial kwi-Candida, i-cryptococcus, i-coloring fungi kunye ne-Aspergillus, kwaye akukho mpembelelo yokuthintela kwezinye iifungi.
Impembelelo yayo yokuthintela kwifungi ngenxa yokungena kwayo kwiiseli zefungi ezithintekayo, apho phantsi kwesenzo se-nucleopyine deaminase, isusa amaqela e-amino ukuba enze i-antimetabolite-5-fluorouracil. Le yokugqibela iguqulwa ibe yi-5-fluorouracil deoxynucleoside kwaye inqanda i-thymine nucleoside synthetase, ivimbela ukuguqulwa kwe-uracil deoxynucleoside kwi-thymine nucleoside, kwaye ichaphazela i-DNA synthesis.
sebenzisa
Antifungals. Isetyenziselwa ikakhulu kwi-candidiasis ye-mucocutaneous, i-candidal endocarditis, i-candidal arthritis, i-cryptococcal meningitis kunye ne-chromomycosis.
Ukusetyenziswa kunye nomthamo Oral, 4 ~ 6g ngosuku, yahlulwe ngamaxesha 4.
ukhuseleko
Ubalo lwegazi kufuneka luhlolwe rhoqo ngexesha lolawulo. Izigulane ezinesifo sesibindi kunye nezintso kunye nezifo zegazi kunye nabasetyhini abakhulelweyo kufuneka basebenzise ngokuqaphela; I-Contraindicated kwizigulane ezinokusilela okukhulu kwezintso.
I-Shading, indawo yokugcina umoya.
