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5-Fluorouracil (CAS# 51-21-8) Umfanekiso okhoyo
  • 5-Fluorouracil(CAS# 51-21-8) 1

5-Fluorouracil (CAS# 51-21-8)

Ipropati yeMichiza:

Ifomula yeemolekyuli C4H3FN2O2
IMisa yeMolar 130.08
Ukuxinana 1.4593 (uqikelelo)
Indawo yokunyibilika 282-286 °C (dec.) (lit.)
Indawo yeBoling 190-200°C/0.1mmHg
Ukunyibilika kwamanzi 12.2 g/L 20 ºC
Ukunyibilika Inyibilika kancinane kwi-ethanol. Iphantse ingabikho kwi-chloroform kwaye inyibilike kwisisombululo se-sodium hydroxide.
Imbonakalo Umgubo omhlophe okanye omhlophe onjengekristale
Umbala mhlophe
Merck 14,4181
I-BRN 127172
pKa pKa 8.0±0.1 (H2O) (Akuqinisekanga);3.0±0.1(H2O) (Akuqinisekanga)
PH 4.3-5.3 (10g/l, H2O, 20℃)
Imeko yoGcino 2-8°C
Uzinzo Izinzile. Ukukhanya okulula. Ukutsha. Ayihambelani ne-oxidizing agents ezinamandla, iziseko ezinamandla.
Inovakalelo Ubuthathaka bomoya
Refractive Index 1.542
MDL MFCD00006018
IiPropati zoMzimba kunye nezeMichiza indawo yokunyibilika 282-286°C (dec.)(lit.)imeko zokugcina Gcina ku-0-5
I-solubility H2O: 10 mg / mL, icacile

yenza umgubo

umbala omhlophe

ukunyibilika kwamanzi 12.2g/L 20 oC
Umoya obuthathaka
merk 14,4181
BRN 127172
Sebenzisa Kumhlaza wenkqubo yokugaya ukutya, umhlaza wentloko kunye nentamo, umhlaza wesibeleko, umhlaza wemiphunga, umhlaza wesibindi, umhlaza wesinyi kunye nonyango lomhlaza wolusu.

Iinkcukacha zeMveliso

Iithegi zeMveliso

Iikhowudi zoMngcipheko I-R22 – Iyingozi xa iginyiwe
I-R20/21/22 – Iyingozi ngokuphefumla, xa udibana nolusu naxa uginyiwe.
I-R52 – Iyingozi kwizinto eziphila emanzini
I-R25 – Inetyhefu xa iginyiwe
Inkcazelo yoKhuseleko S36 – Nxiba iimpahla ezifanelekileyo ezikhuselayo.
S36/37 – Nxiba iimpahla ezifanelekileyo zokukhusela kunye neeglavu.
S36/37/39 – Nxiba iimpahla ezifanelekileyo zokukhusela, iiglavu kunye nokukhusela amehlo/ubuso.
S22 – Musa ukuphefumla uthuli.
S45 - Kwimeko yengozi okanye ukuba uziva ungaphilanga, funa iingcebiso zonyango ngokukhawuleza (bonisa ileyibhile nanini na kunokwenzeka.)
S26 – Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango.
Izazisi ze-UN UN 2811 6.1/PG 3
WGK eJamani 3
RTECS YR0350000
FLUKA BRAND F IIKHOWUDI 10-23
I-TSCA T
Ikhowudi ye-HS 29335995
Inqaku Lengozi Iyacaphukisa / inetyhefu ephezulu
IKlasi yeeNgozi 6.1
Iqela lokuPakisha III
Ubutyhefu I-LD50 ngomlomo kuMvundla: 230 mg / kg

 

Intshayelelo

Le mveliso iqala ukuguqulwa ibe yi-5-fluoro-2-deoxyuracil nucleotides emzimbeni, inqanda i-thymine nucleotide synthase kwaye ivimbele ukuguqulwa kwe-deoxyuracil nucleotides ibe yi-deoxythymine nucleotides, ngaloo ndlela inqanda i-DNA biosynthesis. Ukongezelela, ngokuthintela ukufakwa kwe-uracil kunye ne-rotic acid kwi-RNA, umphumo wokuvimbela i-RNA synthesis ifezekisiwe. Le mveliso liyeza elithile lomjikelo weseli, ikakhulu lithintela iiseli zesigaba se-S.

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