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alpha-Arbutin (CAS# 84380-01-8) Umfanekiso okhoyo
  • alpha-Arbutin(CAS# 84380-01-8) 1

alpha-Arbutin (CAS# 84380-01-8)

Ipropati yeMichiza:

Ifomula yeemolekyuli C12H16O7
IMisa yeMolar 272.25
Ukuxinana 1.556±0.06 g/cm3(Kuxelwe kwangaphambili)
Indawo yokunyibilika 195-196°C
Indawo yeBoling 561.6±50.0 °C(Kuqikelelwe)
Indawo yokuflasha 293.4°C
Ukunyibilika Inyibilika kwi-methanol, i-ethanol, i-DMSO kunye nezinye izinyibilikisi eziphilayo
Uxinzelelo loMphunga 1.9E-13mmHg ku-25°C
Imbonakalo Umgubo omhlophe wekristale
Umbala Mhlophe ukuya kuMhlophe
I-BRN 89675
pKa 10.10±0.15(Kuqikelelwe)
Imeko yoGcino 2-8°C
Refractive Index 1.65
MDL MFCD09838262
IiPropati zoMzimba kunye nezeMichiza Indawo yokunyibilika 195-196°C

Iinkcukacha zeMveliso

Iithegi zeMveliso

Umngcipheko kunye noKhuseleko

WGK eJamani 3

 

Ulwazi

Isishwankathelo i-arbutin yi-hydroquinone glycoside compound, igama lekhemikhali ye-4-hydroxyphenyl-d-glucopyranoside (y), ikhona kwiziqhamo zebhere, i-bilberry kunye nezinye izityalo, yinto entsha engacaphukiyo, engaguqukiyo, i-whitening yendalo esebenzayo kunye nokuhambelana okuqinileyo. I-Arbutin inamaqela amabini asebenzayo kunye nesakhiwo esisebenzayo kwisakhiwo sayo se-molecular: enye i-residu ye-glucose; Elinye liqela lephenolic hydroxyl. Ubume bomzimba be-α-arbutin bubonakala bumhlophe ukuya kumgubo ongwevu okhanyayo, onyibilika ngakumbi emanzini nakwi-ethanol.
ukusebenza kakuhle I-α-arbutin inempembelelo engcono yokwelapha kwizibazi ezibangelwa yi-UV Burns, inomphumo ongcono wokuchasana nokuvuvukala, ukulungiswa kunye nomhlophe. Inokuthintela ukuveliswa kunye nokufakwa kwe-melanin, ukususa amabala kunye namabala.
indlela yokwenza Indlela emhlophe ye-α-arbutin inqanda ngokuthe ngqo umsebenzi we-tyrosinase, ngaloo ndlela inciphisa ukuveliswa kwe-melanin, kunokunciphisa ukuveliswa kwe-melanin ngokuvimbela ukukhula kweeseli okanye i-tyrosinase gene expression. Njengoko i-α-Arbutin iyeyona nto isebenzayo kwaye ikhuseleke ngakumbi yokwenza mhlophe, iinkampani ezininzi zokuthambisa ekhaya naphesheya ziye zamkela i-α-arbutin endaweni ye-β-arbutin njengento edibanisa mhlophe.
Isicelo I-alpha-Arbutin yikhemikhali efana ne-arbutin, inokuthintela ukuveliswa kunye nokubekwa kwe-melanin, ukususa amabala kunye namabala. Iziphumo zibonisa ukuba i-arbutin inokuthintela umsebenzi we-tyrosinase ekugxininiseni okuphantsi, kwaye umphumo wayo wokuthintela kwi-tyrosinase ungcono kune-arbutin. I-alpha-arbutin ingasetyenziswa njenge-arhente emhlophe kwizinto zokuthambisa.
ukuhlanjululwa kunye nokuchongwa isampuli efunyenwe yi-reaction yaqala ikhutshwe nge-ethyl acetate, emva koko ikhutshwe nge-n-butanol, iisampulu zaqokelelwa ngo-evaporation kwi-evaporator ejikelezayo kunye ne-centrifuged. I-supernatant yahlalutywa yi-HPLC kwaye ithelekiswa ne-chromatogram ye-HPLC ye-α-arbutin, ingaba isampuli kunye ne-α-arbutin zinexesha elifanayo lokugcinwa lithelekiswa, kwaye ingaba isampuli iqulethe i-α-Arbutin ifakwe ngaphambili.

Imveliso emva kokutsalwa kunye nokucocwa kwachongwa nge-ion mode ye-LC-ESI-MS/MS. Ngokuthelekisa i-molecular mass ye-α-bear fruit kunye ne-molecular mass ye-α-arbutin esemgangathweni, inokuqinisekiswa ukuba imveliso yi-α-arbutin.
Ukusetyenziswa I-α-arbutin inokuthintela umsebenzi we-tyrosinase kwindawo ephantsi yoxinaniso, umphumo wayo wokuthintela kwi-tyrosinase ungcono kune-arbutin.
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