ALPHA-ISO-METHYLIONONE(CAS#127-51-5)
| Iimpawu ezinobungozi | Xi – Irritant |
| Iikhowudi zoMngcipheko | I-43 - Inokubangela uvakalelo ngoqhagamshelwano lwesikhumba |
| Inkcazelo yoKhuseleko | S24/25-Kuphephe ukudibana nolusu namehlo. S36/37 – Nxiba iimpahla ezifanelekileyo zokukhusela kunye neeglavu. |
| Izazisi ze-UN | UN1230 - iklasi 3 - PG 2 - Methanol, isisombululo |
| WGK eJamani | 2 |
| Ubutyhefu | GRAS(FEMA). |
Intshayelelo
ukwazisa
Umxube we-methyl kunye ne-ethyl isomethyl violet ketone kunye ne-methyl kunye ne-ethyl ortho methyl violet ketone.
indalo
I-Alpha isomethylprednisolone yi-organic compound. Yikristale eqinileyo emfusa. Kwiqondo lobushushu begumbi, inevumba elimnandi elikhethekileyo.
IAlpha isomethylprednisolone yiketone enuka kamnandi. Ifunyenwe kwi-methylation reaction ye-violet alcohol kwaye ibizwa ngokuba yi-isomethyl violet ketone. Isakhiwo sayo se-molekyuli sineringi elivumba elimnandi kunye neqela le-ketone.
Kwiqondo lokushisa kwegumbi, liqinile, kodwa linokuchithwa ngokufudumeza. Ayinyibiliki emanzini, kodwa inokunyibilika kwezinye izinyibilikisi eziphilayo ezifana ne-ethanol kunye ne-dichloromethane. Inochuku ekukhanyeni kwaye inokungena kwi-photolysis reaction phantsi kwe-ultraviolet irradiation.
Ngokumalunga neepropati zeekhemikhali, i-α - isomethylprednisolone i-reactive compound. Inokuthi ingene kwiimpendulo ezifana ne-oxidation, ukunciphisa, ukudibanisa, kunye nokutshintshwa. Isebenza kunye nezinye i-electrophilic reagents ukwenza iimveliso zokongeza. Inokuthi iprotonated phambi kwee-acids ezinamandla. Iyakwazi ukuguqulwa ibe yi-ketone acids ngokuphendula kwe-oxidation.
Indlela yokuvelisa
Le ilandelayo yindlela eqhelekileyo yokuvelisa i-alpha isomethylprednisolone:
Ukulungiswa kwezinto zokuqala: Lungiselela izinto zokuqala, kuquka i-Isobutyl ketone kunye ne-Cyclohexanone. Ezi zimbini zimbini ziyi-precursors ezibalulekileyo ze-synthesis ye-α - isomethylprednisolone.
Ukusetha imeko yokuphendula: Yenza i-isodecanone kunye ne-cyclohexanol phantsi kweemeko ezifanelekileyo. Imeko eqhelekileyo yokusabela kukuqhuba ukusabela phantsi kweemeko ze-acidic, kwaye i-acid catalysts esetyenziswa ngokuqhelekileyo ibandakanya i-sulfuric acid (H2SO4) kunye ne-phosphoric acid (H3PO4).
Amanyathelo okuphendula: Xuba umlinganiselo othile we-isodecanone kunye ne-cyclohexanol, kwaye wongeze i-acid catalyst. Emva koko, ukusabela kuqhutyelwa kwiqondo lokushisa elifanelekileyo, kunye nomgangatho wokushisa oqhelekileyo osetyenziswayo we-50-70 degrees Celsius. Ixesha lokuphendula lidla ngokuba ziiyure ezininzi ukuya kwamashumi eeyure.
Ukwahlula kunye nokuhlanjululwa: Emva kokuba impendulo igqityiwe, imveliso ihlanjululwa kumxube wokuphendula nge-distillation okanye ezinye iindlela zokwahlula.
I-Crystallization kunye nokomisa: I-Crystallize kwaye yomise imveliso ecocekileyo ukuze ufumane imveliso ye-alpha isomethylprednisolone yokugqibela.
