benzyl 3 6-dihydropyridine-1 (2H) -carboxylate (CAS# 66207-23-6)

Intshayelelo

I-N-CBZ-1,2,3,6-tetrahydropyridine, eyaziwa ngokuba yi-carbamate-4-hydroxybenzyl ester-1,2,3,6-tetrahydropyridine, i-organic compound. Oku kulandelayo sintshayelelo kwiipropati zayo, ukusetyenziswa, iindlela zokuvelisa kunye nolwazi lokhuseleko:

Umgangatho:

- N-Cbz-1,2,3,6-tetrahydropyridine yinto eqinileyo emhlophe.

- Izinzile kwiqondo lobushushu begumbi kodwa ibola kumaqondo aphezulu.

- Inokunyibilika kwezinye izinyibilikisi eziphilayo ezifana ne-dimethyl sulfoxide kunye ne-ethanol.

Sebenzisa:

- I-N-Cbz-1,2,3,6-tetrahydropyridine isoloko isetyenziswa njengeqela elikhuselayo kwi-organic synthesis ukukhusela iqela le-amino kwiqela le-amine. Ikhusela iqela le-amino kwiimeko ezingathandekiyo okanye ezinye ii-reagents ekuphenduleni.

Indlela:

- I-N-Cbz-1,2,3,6-tetrahydropyridine inokulungiswa nge-amination kunye ne-acylation. I-Tetrahydropyridine iphendulwa kunye ne-carbamate ngokusebenzisa i-aminoation reaction ukuvelisa i-N-amino-1,2,3,6-tetrahydropyridine. Emva koko, i-N-amino-1,2,3,6-tetrahydropyridine iphendulwa nge-chloroformate ukwenza i-N-Cbz-1,2,3,6-tetrahydropyridine.

Ulwazi ngoKhuseleko:

- Kukho idatha ye-toxicity encinci ye-N-Cbz-1,2,3,6-tetrahydropyridine, kodwa ngokubanzi, ingaba nokucaphuka kunye nobutyhefu kubantu.

- Gwema ukudibana ngqo nolusu kunye nokuphefumla uthuli lwayo ngexesha lokusetyenziswa.

- Izilumkiso ezifanelekileyo, ezinjengeeglavu kunye nezixhobo zokuphefumla, kufuneka zithathwe ngexesha lokuphatha kunye nokugcinwa.

- Xa usebenzisa kwaye ugcina, nceda ulandele izikhokelo ezifanelekileyo zokuphatha ngokukhuselekileyo kunye nemimiselo.