N-(tert-Butoxycarbonyl)-L-aspartic acid (CAS# 13726-67-5)
Umngcipheko kunye noKhuseleko
| Iimpawu ezinobungozi | Xn – Iyingozi |
| Iikhowudi zoMngcipheko | I-R20/21/22 – Iyingozi ngokuphefumla, xa udibana nolusu naxa uginyiwe. R36/37/38 – Ukucaphuka kwamehlo, inkqubo yokuphefumla kunye nolusu. |
| Inkcazelo yoKhuseleko | S26 – Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango. S36 – Nxiba iimpahla ezifanelekileyo ezikhuselayo. S24/25-Kuphephe ukudibana nolusu namehlo. |
| WGK eJamani | 3 |
| Ikhowudi ye-HS | 2924 19 00 |
N-(tert-Butoxycarbonyl)-L-aspartic acid (CAS# 13726-67-5) Intshayelelo
I-Boc-L-aspartic acid yikhompawundi ephilayo edla ngokusetyenziswa njengeqela elikhuselayo kwi-peptide synthesis. Ifomula yayo yeekhemikhali yi-C13H19NO6 kunye nobunzima bayo be-molecular yi-293.29. I-Boc imele i-N-tert-butoxycarbonyl.
I-Boc-L-aspartic acid inezi mpawu zilandelayo:
1. Imbonakalo: i-crystalline powder engenambala;
2. indawo yokunyibilika: malunga ne-152-155 ℃;
3. Ukunyibilika: Inyibilika kwezinye izinyibilikisi eziphilayo, ezifana ne-dimethyl sulfoxide kunye ne-dichloromethane, ezinganyibilikiyo emanzini;
4. ukuzinza: ukubola kunokwenzeka kwimeko ye-oxidant enamandla kunye nokukhanya.
Ukusetyenziswa okuphambili kwe-Boc-L-aspartic acid njengeqela elikhuselayo kwi-peptide synthesis. Ikhusela iqela le-amine kwicala lekhonkco le-L-aspartic acid ukunqanda ukuphendula okungafunekiyo. Ngexesha le-peptide synthesis, i-Boc-L-aspartic acid isabela kunye nezinye ii-amino acids okanye amacandelo e-peptide ukwenza amakhonkco amatsha e-peptide. Emva kokugqitywa kwe-synthesis, iqela elikhuselayo linokususwa ngonyango lwe-asidi ukufumana i-peptide ekujoliswe kuyo okanye iprotheni.
I-Boc-L-aspartic acid ilungiswa ngokubanzi ngeendlela ezaziwayo zokwenziwa. Ngokufutshane, i-asidi ye-L-aspartic inokwenziwa ngokuphendula i-L-aspartic acid kunye ne-t-Boc-L acid kunye ne-dimethylformamide. Iindlela ezikhethekileyo zokwenziwa zingafumaneka kwiincwadi ezifanelekileyo zeekhemikhali.
Ngokumalunga nolwazi lokhuseleko, kufuneka unikele ingqalelo kula manqaku alandelayo:
1. I-Boc-L-aspartic acid yikhemikhali enetyhefu ethile. Amanyathelo afanelekileyo okukhusela kufuneka athathwe ngexesha lokusebenza, njengokugqoka iiglavu, izibuko kunye neempahla zebhubhoratri;
2. ugweme ukuphefumla umgubo okanye isisombululo, ugweme ukudibanisa nolusu kunye namehlo;
3. Xa usebenzisa kunye nokuphatha i-Boc-L-aspartic acid, kufuneka ivalwe kwaye igcinwe ukuze ugweme ukudibanisa ne-oxidants kunye nokukhanya okunamandla;
4. Xa ujongene nenkunkuma ye-Boc-L-aspartic acid, kufuneka ilahlwe ngokuhambelana nemimiselo yendawo.
I-Boc-L-aspartic acid inezi mpawu zilandelayo:
1. Imbonakalo: i-crystalline powder engenambala;
2. indawo yokunyibilika: malunga ne-152-155 ℃;
3. Ukunyibilika: Inyibilika kwezinye izinyibilikisi eziphilayo, ezifana ne-dimethyl sulfoxide kunye ne-dichloromethane, ezinganyibilikiyo emanzini;
4. ukuzinza: ukubola kunokwenzeka kwimeko ye-oxidant enamandla kunye nokukhanya.
Ukusetyenziswa okuphambili kwe-Boc-L-aspartic acid njengeqela elikhuselayo kwi-peptide synthesis. Ikhusela iqela le-amine kwicala lekhonkco le-L-aspartic acid ukunqanda ukuphendula okungafunekiyo. Ngexesha le-peptide synthesis, i-Boc-L-aspartic acid isabela kunye nezinye ii-amino acids okanye amacandelo e-peptide ukwenza amakhonkco amatsha e-peptide. Emva kokugqitywa kwe-synthesis, iqela elikhuselayo linokususwa ngonyango lwe-asidi ukufumana i-peptide ekujoliswe kuyo okanye iprotheni.
I-Boc-L-aspartic acid ilungiswa ngokubanzi ngeendlela ezaziwayo zokwenziwa. Ngokufutshane, i-asidi ye-L-aspartic inokwenziwa ngokuphendula i-L-aspartic acid kunye ne-t-Boc-L acid kunye ne-dimethylformamide. Iindlela ezikhethekileyo zokwenziwa zingafumaneka kwiincwadi ezifanelekileyo zeekhemikhali.
Ngokumalunga nolwazi lokhuseleko, kufuneka unikele ingqalelo kula manqaku alandelayo:
1. I-Boc-L-aspartic acid yikhemikhali enetyhefu ethile. Amanyathelo afanelekileyo okukhusela kufuneka athathwe ngexesha lokusebenza, njengokugqoka iiglavu, izibuko kunye neempahla zebhubhoratri;
2. ugweme ukuphefumla umgubo okanye isisombululo, ugweme ukudibanisa nolusu kunye namehlo;
3. Xa usebenzisa kunye nokuphatha i-Boc-L-aspartic acid, kufuneka ivalwe kwaye igcinwe ukuze ugweme ukudibanisa ne-oxidants kunye nokukhanya okunamandla;
4. Xa ujongene nenkunkuma ye-Boc-L-aspartic acid, kufuneka ilahlwe ngokuhambelana nemimiselo yendawo.
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