BOC-GLY-GLY-GLY-OH (CAS# 28320-73-2)

Intshayelelo

I-Tert-Butoxycarbonylglycyl glycylglycine (i-Boc-Gly-Gly-Gly-OH) yikhompawundi ephilayo enezi mpawu zilandelayo:

Indalo:

-Imbonakalo: ngokuqhelekileyo ikristale emhlophe okanye i-crystalline powder

-Ifomula yemolekyuli: C17H30N4O7

-Ubunzima bemolekyuli: 402.44g / mol

-Indawo yokunyibilika: malunga ne-130-132 ° C

-I-Solubility: I-Soluble kwi-solvents ye-organic efana ne-dimethylformamide (DMF), i-dichloromethane, i-chloroform, njl., i-insoluble emanzini.

Sebenzisa:

I-Boc-Gly-Gly-Gly-OH isetyenziswa ngokuqhelekileyo kwi-organic synthesis, ngokukodwa njengamaqela akhuselayo okanye amaqela. Ingasetyenziselwa njengeqela elikhuselayo le-amino acids ukuthintela ukusabela okungaqhelekanga, kwaye isetyenziswa ngokuqhelekileyo kwi-synthesis yesigaba esiqinileyo, i-peptide synthesis kunye ne-drug synthesis.

Indlela:

Indlela eqhelekileyo yokulungiselela i-Boc-Gly-Gly-Gly-OH kukuzisa iqela elikhuselayo le-tert-butoxycarbonyl kwiqela le-carboxyl le-glycine. Amanyathelo athile abandakanya:

1. I-Glycine iphendulwa ngomxube we-sodium nitrite kunye ne-asidi ye-sulfuric ukufumana i-tert-butoxycarbonyl glycinate.

2. Iqela elikhuselayo le-Ester lisuswa yi-hydrolysis reaction ukuze lifumane i-Boc-glycine.

3. Phinda la manyathelo angasentla kabini ukwazisa iqela le-carboxyl le-glycine kumaqela amabini okukhusela i-tert-butoxycarbonyl ngokulandelelana ukufumana i-Boc-Gly-Gly-Gly-OH.

Ulwazi ngoKhuseleko:

Ukusetyenziswa kwe-Boc-Gly-Gly-Gly-OH kufuneka kuthathelwe ingqalelo le miba yokhuseleko ilandelayo:

-Kuphephe ukudibana nolusu kunye namehlo, njengoko kunokucaphukisa ulusu kunye namehlo.

-Nxiba iiglavu ezifanelekileyo zokukhusela, izibuko kunye nempahla yokukhusela ngexesha lokusebenza.

-Isebenza kwindawo engenamoya ukuphepha ukuphefumla uthuli okanye umphunga wayo.

-kufuneka igcinwe kude nomlilo, ubushushu kunye ne-oxidant, gcina isitya sivaliwe, sigcinwe kwindawo epholileyo, eyomileyo.