I-Boc-N-beta-Trityl-L-asparagine (CAS# 132388-68-2)

Inkcazelo yoKhuseleko	S22 – Musa ukuphefumla uthuli. S24/25-Kuphephe ukudibana nolusu namehlo.
WGK eJamani	3
Ikhowudi ye-HS	2924 29 70
IKlasi yeeNgozi	OKUTHUMEKAYO

I-NAA-tert-butoxycarbonyl N Γ-trityl aspartamide yi-organic compound, ngokuqhelekileyo kubhekiselwa kuyo ngesifinyezo esithi Boc-Phe-OtBu. Ineformula C30H37NO4 kwaye iqinile emhlophe.Indalo:
I-Boc-Phe-OtBu i-hydrophobic kwaye ayinakunyibilika ngokulula emanzini, kodwa inyibilika ngokulula kwizinyibilikisi ze-organic ezifana ne-methanol, i-ethanol kunye ne-dichloromethane. Izinzile ekukhanyeni nakubushushu.

Sebenzisa:
I-Boc-Phe-OtBu zisetyenziswa ikakhulu ukukhusela amaqela kunye ne-reaction intermediates kwi-organic synthesis. Kwi-synthesis, ingasetyenziselwa ukukhusela i-amino acids enevumba elimnandi, kwi-synthesis ye-polypeptides kunye neeprotheni, ukukhusela amaqela asebenzayo ukukhusela ukwenzeka kweempendulo zecala. Ukongeza, ingasetyenziselwa ukulungiselela ezinye iikhompawundi, ezifana neziyobisi, idayi kunye nezinto eziphilayo.

Indlela yokulungiselela:
Ukulungiswa kwe-Boc-Phe-OtBu kufezekiswa ikakhulu ngokusabela kweekhemikhali. Enye indlela eqhelekileyo kukusabela i-p-benzoic acid kunye ne-t-butyl hydroxyformate ukuvelisa i-p-tert-butoxycarbonyl benzoate. Emva koko isabela nge-triphenylamine ukunika imveliso yokugqibela i-Boc-Phe-OtBu.

Ulwazi ngoKhuseleko:
I-Boc-Phe-OtBu ikhuselekile ngokwentelekiso phantsi kosetyenziso oluqhelekileyo. Nangona kunjalo, njengekhemikhali, kusafuneka igcinwe kwaye iphathwe ngokufanelekileyo. Gwema ukudibanisa nee-oxidants ezinamandla, thintela ukuphefumla uthuli kwaye ugweme ukudibanisa kwesikhumba. Ebudeni bokusebenzisa, nxiba izixhobo ezifanelekileyo zokuzikhusela, ezinjengeeglavu neendondo zokuzikhusela. Xa kwenzeka ukudibana ngengozi okanye ukungeniswa, funa iingcebiso zonyango ngokukhawuleza kwaye unike ulwazi kugqirha malunga nekhemikhali. Imithetho nemigaqo yokhuseleko yasekuhlaleni kufuneka ilandelwe xa kusingathwa naxa kulahlwa inkunkuma.