Cbz-L-Glutamic acid 1-benzyl ester (CAS# 3705-42-8)
Intshayelelo
I-Z-Glu-OBzl (Z-Glu-OBzl) i-organic compound isetyenziswa ngokuqhelekileyo njengeqela elikhuselayo le-amino acids. Oku kulandelayo yinkcazo yeepropati, ukusetyenziswa, ukulungiswa kunye nolwazi lokhuseleko lwekhompawundi:
Indalo:
-Ifomula yemolekyuli: C17H17NO4
-Ubunzima bemolekyuli: 303.32g / mol
-Imbonakalo: Umgubo omhlophe wekristale
-Indawo yokunyibilika: 84-85°C
-I-Solubility: I-Soluble kwii-solvents eziphilayo ezifana ne-dimethyl sulfoxide kunye ne-dimethylformamide
- Iqela elikhuselayo le-Cbz linokususwa nge-palladium hydride catalyst phantsi kweemeko ze-acidic
Sebenzisa:
- I-Z-Glu-OBzl liqela elikhuselayo le-glutamic acid (Glu), elingasetyenziselwa ukuhlanganiswa kwe-amino acid derivatives, i-polypeptides kunye neeprotheni.
-Njengeqela elikhuselayo le-amino acids kwi-synthetic organic compounds, linokukhusela iqela le-amine le-glutamic acid, lithintele ukuba lingachaphazeleki kwiimpendulo ezingezizo, kwaye liququzelele ukususwa xa kuyimfuneko.
Indlela yokulungiselela:
-Ukulungiswa kwe-Z-Glu-OBzl ngokuqhelekileyo kubandakanya inkqubo yamanyathelo amaninzi kwaye ibandakanya uchungechunge lwee-chemical reactions. Enye yeendlela eziqhelekileyo kukukhusela kuqala iqela le-carboxyl ye-glutamic acid njenge-t-butoxycarbonyl ester (Boc) kwaye emva koko ukhusele iqela le-amino njenge-Cbz. Ekugqibeleni, imveliso efunwayo i-Z-Glu-OBzl yenziwa ngokusabela nge-benzyl chloroformate.
Ulwazi ngoKhuseleko:
- I-Z-Glu-OBzl kufuneka iphathwe njengama-compounds acasulayo kwaye ugweme ukudibanisa ngokuthe ngqo kwesikhumba kunye namehlo.
-Xa isetyenziswe kwibhubhoratri, iinkqubo ezichanekileyo zokhuseleko kufuneka zilandelwe, kubandakanywa ukunxiba iiglasi zokukhusela, iiglavu kunye neengubo zebhubhoratri.
-Ukuphefumla okanye ukungeniswa kwekhompawundi kufuneka kugwenywe kwaye amanyathelo okuthintela umlilo kunye nokuqhuma kufuneka kuthathwe ngexesha lokugcinwa.
-I-compound kufuneka ifakwe kwindawo enomoya ococekileyo ngexesha lokucubungula, kwaye inkunkuma kufuneka ilahlwe ngokufanelekileyo ngokuhambelana nemimiselo yendawo.
