I-Ethyl 1-(4-methoxyphenyl)-6-(4-aminophenyl)-7-oxo-4 5 6 7-tetrahydro-1H-pyrazolo[3 4-c]pyridine-3-carboxylate（CAS# 503615-07-4 )

Intshayelelo

Oku kulandelayo kukwaziswa kwiipropati, ukusetyenziswa, iindlela zokulungiselela kunye nolwazi olukhuselekileyo lwe-apixaban ephakathi kwe-3:

Umgangatho:

I-Apixaban ephakathi kwe-3 yi-organic compound. Iqinile kwaye iyanyibilika kwizinyibilikisi eziphilayo ezifana ne-ether kunye ne-ethyl acetate.

Ukusetyenziswa: Ngokuqhelekileyo isetyenziselwa i-anesthesia yokuhlinzwa kunye nokunyangwa kweentlungu ezinzima.

Indlela:

Indlela yokulungiselela i-apixaban ephakathi kwe-3 inokuqhutywa ngamanyathelo alandelayo: i-p-nitrobenzoic acid iphendulwa kunye ne-hypobutylthiourea kwi-co-presence ye-acetic acid kunye ne-thionyl chloride ukufumana i-N-(p-nitrophenyl) -N-(hypobutylthioyllurea) acid formic, kwaye emva koko, wasabela kunye sodium hydroxide kwi sodium oxide kunye nesisombululo methanol ukufumana i-apixaban ephakathi 3.

Ulwazi loKhuseleko: Iinkqubo zokusebenza ezingqongqo zokhuseleko kufuneka zilandelwe xa usebenzisa kwaye uphatha le khompawundi. Ukudibana ngokuthe ngqo okanye ukuphefumla kunokubangela ingozi enkulu kwimpilo yabantu. Ulwazi lwayo oluthile lokhuseleko kufuneka luvavanywe kwaye luqhutywe ngokuhambelana nemimiselo efanelekileyo kunye nezikhokelo zokuqinisekisa ukusetyenziswa ngokukhuselekileyo kunye nokuphathwa. Xa kusenziwa amalinge okwenziwa kweekhemikhali, kufuneka zisetyenziswe phantsi kweemeko ezifanelekileyo zelabhoratri kunye nezixhobo zokuzikhusela ezifana neeglasi zekhemikhali, iiglavu zokhuselo, kunye nempahla yokhuselo kufuneka isetyenziswe.