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I-Ethyl 3-(2-((4-cyanophenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate（CAS# 211915-84-3 ) Umfanekiso okhoyo
  • I-Ethyl 3-(2-((4-cyanophenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate（CAS# 211915-84-3 ) 1

I-Ethyl 3-(2-((4-cyanophenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate（CAS# 211915-84-3 )

Ipropati yeMichiza:

Ifomula yeemolekyuli I-C27H26N6O3
IMisa yeMolar 482.53
Ukuxinana 1.25±0.1 g/cm3(Kuxelwe kwangaphambili)
Indawo yokunyibilika 149-151°C
Indawo yeBoling 756.4±60.0 °C(Kuqikelelwe)
Indawo yokuflasha 411.245°C
Ukunyibilika I-DMSO (Kancinci, i-Sonicated), i-Methanol (Kancinci, i-Sonicated)
Uxinzelelo loMphunga 0mmHg ku-25°C
Imbonakalo Iqinile
Umbala Mhlophe ukuya kwiPale Beige
pKa 4.21±0.10(Kuqikelelwe)
Imeko yoGcino Gcina kwindawo emnyama, umoya ongena ngaphakathi, ubushushu begumbi
Refractive Index 1.64

Iinkcukacha zeMveliso

Iithegi zeMveliso

 

Intshayelelo

N-[[2-[[(4-cyanobenzenyl)amine]methyl]-1methyl-1H-5-benzimidazole]carbonyl]3-aminobenzoyl]N-2-pyridyl-b-alanine ethyl ester, efinyeziweyo njenge-N-PCBMITPAAE. Oku kulandelayo sintshayelelo kubume bayo, ukusetyenziswa, ukulungiswa kunye nolwazi lokhuseleko:

 

Umgangatho:

Imbonakalo: ikristale engenambala eqinileyo okanye etyheli ekhanyayo.

Ukunyibilika: I-N-PCBMITPAAE iyanyibilika kwezinye izinyibilikisi zendalo, njenge-dimethyl sulfoxide kunye ne-dichloromethane. Iphantse yanganyibiliki emanzini.

 

Sebenzisa:

I-N-PCBMITPAAE isetyenziswa ngokuqhelekileyo kuphando olwenziweyo kwicandelo lekhemistri. Inomsebenzi onzima we-molecular kunye namaqela asebenzayo, kwaye ingasetyenziselwa njenge-reagent, i-catalyst okanye i-agent eyongezelelweyo kwi-organic synthesis.

 

Indlela:

Indlela yokulungiselela ye-N-PCBMITPAAE inzima kwaye idla ngokufuna ukuphendulwa kwamanyathelo amaninzi. Indlela eqhelekileyo yokulungiselela ibandakanya la manyathelo alandelayo: ukuhlanganiswa kwe-4-cyanoaniline kunye ne-1-methyl-1H-5-benzimidazole, kwaye emva koko i-reaction kunye ne-carboatelic acid ukwenza i-N- [(4-cyanobenzene) methyl]-1-methyl-1H- I-5-benzimidazole-2-carboxylate. Okulandelayo, isabela nge-3-aminobenzoyl chloride ukwenza i-N-[(4-cyanobenzene)methyl]-1-methyl-1H-5-benzimidazole-2-carboxylic acid 3-aminobenzoyl ester. Imveliso yokugqibela, i-N-PCBMITPAAE, yenziwe ngokuphendula nge-2-pyridyl-β-alanine ethyl ester.

 

Ulwazi ngoKhuseleko:

Ubume be-N-PCBMITPAAE bunzima ngakumbi, kwaye isilumkiso siyafuneka ngexesha lokusetyenziswa kunye nokusebenza. Kufanele kulandelwe iindlela ezifanelekileyo zaselabhoratri kuze kuthatyathwe amanyathelo okhuseleko afanelekileyo, anjengokunxiba iiglavu zokuzikhusela, izikhuselo zobuso, nezinxibo zamehlo ezikhuselayo. Kufuneka igcinwe kude nemithombo yokutshisa kunye ne-oxidizing agents eyomeleleyo, kwaye iimeko ezifanelekileyo zokungenisa umoya kufuneka zigcinwe. Xa ugcina kwaye uphatha ikhemikhali, nceda uyilawule ngokufanelekileyo ukuthintela iingozi.

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