FMOC-D-NVA-OH (CAS# 144701-24-6)

I-FMOC-D-NVA-OH (i-CAS # 144701-24-6) liqela elikhusela i-amino acid elisetyenziswa ngokuqhelekileyo kwi-synthesis ye-peptides kunye neeprotheni. Oku kulandelayo yinkcazo yendalo, ukusetyenziswa, ukwenziwa kunye nolwazi lokhuseleko lwe-fmoc-D-norvaline:

Indalo:
I-fmoc-D-norvaline iqinile emhlophe, ngokuqhelekileyo ikwimo yomgubo. Ichithwa kakuhle kwii-agent zokunyibilika ezifana ne-N, N-dimethylformamide (DMF) okanye i-dichloromethane (DCM). Ikhompawundi inozinzo oluphezulu lwe-thermal kwaye inokuzinza kwii-solvents eziqhelekileyo ze-organic.

Sebenzisa:
I-fmoc-D-norvaline isetyenziswa kakhulu njengeqela elikhuselayo le-amino acid kwi-synthesis ye-peptides kunye neeprotheni. Inokudibaniswa nezinye i-amino acids nge-slid-phase synthesis, enokuthi ikhusele okwethutyana ezinye i-amino acids ngexesha lokudibanisa. Nje ukuba i-peptide chain synthesis igqityiwe, iqela elikhuselayo le-Fmoc linokususwa ngonyango olusisiseko.

Indlela:
I-fmoc-D-norvaline idla ngokulungiswa nge-chemical synthesis, kunye ne-D-norvaline njengento yokuqala. I-synthesis ibandakanya ukusabela kwe-norvaline kunye neqela elikhuselayo le-Fmoc ukwazisa iqela le-Fmoc ngokusabela endaweni. Ekugqibeleni fumana i-fmoc-D-norvaline.

Ulwazi ngoKhuseleko:
I-fmoc-D-norvaline ikhuselekile ngokwentelekiso phantsi kweemeko eziqhelekileyo zokusebenza zelabhoratri, ezinye iindlela zokusebenza ezisisiseko zisafuna ukulandelwa. Kuphephe ukudibana nolusu kunye namehlo ngexesha lokusetyenziswa, kwaye uqinisekise ukuba usebenza kwindawo engenamoya. Izixhobo ezifanelekileyo zokuzikhusela, ezinjengeeglavu zelebhu kunye neendondo zokhuseleko, kufuneka zinxitywe xa uphethe ikhompawundi. Ukongeza, inkunkuma kufuneka ilahlwe ngokufanelekileyo kwaye ilahlwe ngokuhambelana nemimiselo efanelekileyo. Ukuba kwenzeka nayiphi na ingozi yengozi, amanyathelo oncedo lokuqala ahambelanayo kufuneka athathwe ngokukhawuleza. Ekusetyenzisweni nasekugcinweni kwe-fmoc-D-norvaline, imigaqo efanelekileyo yokhuseleko lweekhemikhali kufuneka igcinwe.