FMOC-Glycine (CAS# 29022-11-5)
| Iimpawu ezinobungozi | Xi – Irritant |
| Iikhowudi zoMngcipheko | 36/37/38 – Ukucaphukisa amehlo, inkqubo yokuphefumula kunye nolusu. |
| Inkcazelo yoKhuseleko | S24/25-Kuphephe ukudibana nolusu namehlo. S36 – Nxiba iimpahla ezifanelekileyo ezikhuselayo. S26 – Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango. |
| WGK eJamani | 3 |
| Ikhowudi ye-HS | 29242995 |
Intshayelelo
I-N-Fmoc-glycine yinto ebalulekileyo ye-amino acid derivative, kunye negama layo lekhemikhali yi-N- (9H-fluoroeidone-2-oxo) -glycine. Oku kulandelayo kukwazisa kwiipropati, ukusetyenziswa, iindlela zokulungiselela kunye nolwazi olukhuselekileyo lwe-N-Fmoc-glycine:
Umgangatho:
- Imbonakalo: Emhlophe okanye emhlophe eqinileyo
- Ukunyibilika: Inyibilika kwizinyibilikisi ze-organic ezifana ne-dimethyl sulfoxide (DMSO) kunye ne-methylene chloride, i-soluble kancinane etywaleni, iphantse inganyibiliki emanzini.
Sebenzisa:
I-N-Fmoc-glycine isetyenziswa ikakhulu kwi-peptide synthesis kwi-slid-phase synthesis (SPPS). Njenge-amino acid ekhuselweyo, yongezwa kwikhonkco le-polypeptide ngokudibanisa kwesigaba esiqinileyo, kwaye ekugqibeleni i-peptide ekujoliswe kuyo ifunyenwe ngokusabela kwamaqela akhuselayo.
Indlela:
Ukulungiswa kwe-N-Fmoc-glycine ngokuqhelekileyo kwenziwa ngokuphendula kweekhemikhali. I-Glycine isabela nge-N-fluorophenyl methyl alcohol kunye nesiseko (umzekelo, i-triethylamine) ukuvelisa i-N-fluorophenylmethyl-glycine hydrochloride. Emva koko, i-hydrochloric acid isuswa luhlobo oluthile lwe-deacidifier, njenge-dimethyl sulfoxide okanye i-sec-butanol, ukunika i-N-Fmoc-glycine.
Ulwazi ngoKhuseleko:
I-N-Fmoc-Glycine ikhuselekile ngokwentelekiso phantsi kweemeko eziqhelekileyo zokusebenza
- Nceda unxibe izixhobo ezifanelekileyo zokuzikhusela ezifana neeglavu zelebhu kunye nokhuseleko lwamehlo.
• Kuphephe ukuphefumla okanye ukudibana nolusu namehlo.
- Landela yonke imimiselo yokhuseleko efanelekileyo kunye neeprothokholi zaselabhoratri xa ugcina kwaye uphatha.
- Nika ingqalelo ekuqokeleleni komlilo kunye nombane ongatshintshiyo ngexesha lenkqubo yokuphatha ukukhusela umngcipheko womlilo kunye nokuqhuma.
- Ukulahlwa ngokufanelekileyo kwenkunkuma ngokuhambelana neemfuno zokugcinwa nokulahlwa kwenkunkuma.
