I-Fmoc-L-2-Aminobutyric acid (CAS# 135112-27-5 )

Inkcazelo yoKhuseleko	S22 – Musa ukuphefumla uthuli. S24/25-Kuphephe ukudibana nolusu namehlo.
WGK eJamani	3
Ikhowudi ye-HS	2924 29 70
IKlasi yeeNgozi	OKUTHUMEKAYO

I-L-2- (i-fluorenylmethoxycarbonylamino) i-asidi ye-butyric, eyaziwa ngokuba yi-Fmoc-glutamic acid (L-2- (9-fluorenylmethoxycarbonylamino) i-butyric acid), yinto ephilayo. Oku kulandelayo yinkcazo yezinye iimpawu zayo, ukusetyenziswa, iindlela kunye nolwazi lokhuseleko:

Indalo:
-Imbonakalo: Umgubo wekristale ongenambala okanye otyheli kancinci;
-Ifomula yemolekyuli: C26H23NO4;
-Ubunzima bemolekyuli: 413.47g / mol;
-indawo yokunyibilika: malunga ne-166-168 ℃;
-I-Solubility: I-Fmoc-glutamic acid iyanyibilika kwii-solvents eziphilayo ezifana ne-dimethylformamide kunye ne-hydrofluoric acid.

Sebenzisa:
I-Fmoc-glutamic acid, njengeqela elikhuselayo leqela, lihlala lisetyenziswa kwi-peptide synthesis, ngokukodwa kwi-synthesis ye-peptide ezinzileyo kunye ne-synthesis ye-Levenstein peptides (i-Levenshtein peptide). Ingasetyenziswa njenge-synthetic intermediate ye-amino acids, okanye isetyenziswe kwi-synthesis yesigaba esiqinileyo, i-chromatography yolwelo oluphezulu olusebenzayo, njl.

Indlela yokulungiselela:
Ukulungiswa kwe-Fmoc-glutamic acid ngokubanzi kubandakanya la manyathelo alandelayo:
1. Kwinkqubo ye-anhydrous, i-L-glutamic acid isabela nge-Fmoc-OSu (i-fluorenylmethoxycarbonyl-chloro anhydride), kunye ne-sodium chloride (NaCl) isetyenziselwa ukukhuthaza ukusabela ukuvelisa i-Fmoc-glutamic acid Fmoc-A ityuwa.
2. Kwityuwa ye-Fmoc-glutamic acid, ichithwa kwi-solvent (efana ne-dimethylformamide) kwaye ixhomekeke kwindlela yokucoca efanelekileyo (njenge-crystallization) ukufumana i-Fmoc-glutamic acid.

Ulwazi ngoKhuseleko:
I-Fmoc-glutamic acid iqhele ukuzinza kwaye iphantsi inetyhefu phantsi komsebenzi wesiqhelo. Kodwa njengekhompawundi ephilayo, kusafuneka kuqwalaselwe la manyathelo okhuseleko alandelayo:
-Kuphephe ukuphefumla uthuli, ukudibana nolusu kunye namehlo;
-Ngexesha lokusebenza, nxiba iiglavu zokukhusela, iiglasi kunye nempahla yokukhusela ehlangabezana neemfuno zokhuseleko;
-Sebenzisa kwindawo enomoya ococekileyo ukuphepha ukuvezwa ngokuthe ngqo ixesha elide;
-Ukuba inkunkuma evela kule ngqungquthela kufuneka ilahlwe, kufuneka ilahlwe ngokufanelekileyo ngokuhambelana nemimiselo yendawo.