I-Fmoc-L-Glutamic acid 1-tert-butyl ester (CAS# 84793-07-7)

Intshayelelo

I-Fluorene methoxycarbonyl-L-glutamate-1-tert-butyl ester, eyaziwa ngokuba yi-Fmoc-L-glutamic acid-1-tert-butyl ester, i-organic compound esetyenziswa ngokuqhelekileyo kwi-peptide synthesis kunye ne-slid-phase synthesis in organic synthesis.

Umgangatho:

I-Fluorene methoxycarbonyl-L-glutamic acid-1-tert-butyl yinto eqinileyo enekristale ezimhlophe ukuya kumthubi. Ine-solubility ephantsi emanzini kodwa i-solubility efanelekileyo kwii-solvents eziphilayo ezifana ne-dimethyl sulfoxide okanye i-methanol.

Sebenzisa:

I-Fluorene methoxycarbonyl-L-glutamic acid-1-tert-butyl yinto eqhelekileyo esetyenziselwa ukukhusela i-amino acid kwi-peptide synthesis. Ingasetyenziselwa ukukhusela iqela ngokusabela, ukuze ibonakale kwi-synthesis kunye nokwandiswa kwetsheyini yepeptide. Le khompawundi ifaneleka ngokukodwa kwi-slid-phase synthesis, apho amatyathanga e-peptide adityaniswa kwi-amino acids ekhuselayo kumasebe e-resin.

Indlela:

Ukulungiswa kwe-fluorene methoxycarbonyl-L-glutamic acid-1-tert-butyl idla ngokufezekiswa ngokuhlanganiswa kweekhemikhali. I-Fluorene methanol idityaniswa okokuqala kwi-fluorene carboxyl chloride ngokusabela kwekhemikhali, emva koko isebenze nge-L-glutamic acid ukwenza i-fluorene methoxycarbonyl-L-glutamic acid, kwaye ekugqibeleni iphendule nge-tert-butanol ukwenza imveliso yokugqibela.

Ulwazi ngoKhuseleko:

I-Fluorene methoxycarbonyl-L-glutamic acid-1-tert-butyl ngokuqhelekileyo ithathwa ngokuba ayinayo ityhefu ecacileyo ebantwini phantsi kweemeko eziqhelekileyo zovavanyo. Iiprothokholi ezifanelekileyo zokhuseleko zelabhoratri kufuneka zilandelwe ngexesha lokuphatha, kubandakanywa ukunxiba iiglavu zokhuselo kunye neeglasi, kunye nokusebenza phantsi kweemeko ezinomoya owaneleyo.