I-Fmoc-L-glutamic acid-gamma-benzyl ester (CAS# 123639-61-2)

I-Fluorene methoxycarbonyl-L-glutamic acid-Γ-benzyl yi-organic compound esetyenziswa kwi-peptide synthesis kwi-slide-phase synthesis. Ubume bayo:
- Imbonakalo: Okumhlophe ukuya kumthubi okuqinileyo
-Ukunyibilika: I-Fmoc-L-Glu(OtBu)-OH inokunyibilika okulungileyo phakathi kwezinyibilikisi eziqhelekileyo zezinto eziphilayo.

Ukusetyenziswa okuphambili kwe-Fmoc-L-Glu (OtBu)-OH njengeqela elikhuselayo kwi-peptide synthesis. Xa udibanisa amatyathanga e-peptide, i-Fmoc-L-Glu(OtBu)-OH ibophelela kwi-amino acids, ikhusela umsebenzi wabo ngokuchasene neempendulo ezingezizo kunye nezinye ii-reactants. Emva kokuba impendulo igqityiwe, i-Fmoc-L-Glu (OtBu) -OH inokususwa ngokususa iqela elikhuselayo ukubuyisela umsebenzi we-amino acids.

Ukulungiswa kwe-Fmoc-L-Glu(OtBu)-OH inzima kwaye ifuna ngokubanzi ukusetyenziswa kwamanyathelo e-organic synthesis. I-Glutamic acid iphendulwa kunye ne-bromoacetate ukufumana i-ethyl glutamate. Emva koko, i-ethyl glutamate iphendulwa nge-benzyl yotywala ukwenza i-ethyl glutamate benzyl alcohol ester. I-Ethyl glutamate benzyl alcohol ester yaphendulwa kunye neFmoc-Cl ukuvelisa imveliso ekujoliswe kuyo Fmoc-L-Glu(OtBu)-OH.

Ulwazi ngoKhuseleko: I-Fmoc-L-Glu(OtBu)-OH lichiza lelebhu kwaye kufuneka lisetyenziswe phantsi komsebenzi okhuselekileyo welebhu. Landela iinkqubo zokhuseleko lwaselabhoratri ngokubanzi, kubandakanywa ukunxiba izixhobo zokuzikhusela (umzekelo, iiglavu zaselebhu, iiglasi, njl.njl.), ukunqanda ukudibana nolusu nokuphefumla, kunye nokusebenza kwilabhoratri engenamoya. Ikhompawundi kufuneka igcinwe kwisikhongozeli esingangeni moya, kude nomlilo kunye nee-oxidants.