I-Fmoc-L-homophenylalanine (CAS# 132684-59-4)
Umngcipheko kunye noKhuseleko
| Iimpawu ezinobungozi | Xi – Irritant |
| Iikhowudi zoMngcipheko | 36/37/38 – Ukucaphukisa amehlo, inkqubo yokuphefumula kunye nolusu. |
| Inkcazelo yoKhuseleko | S22 – Musa ukuphefumla uthuli. S24/25-Kuphephe ukudibana nolusu namehlo. S44 - S35 – Esi sixhobo kunye nesingxobo saso kufuneka silahlwe ngendlela ekhuselekileyo. S28 – Emva kokudibana nolusu, hlamba ngoko nangoko ngeesepha ezininzi. S7 – Gcina isikhongozeli sivalwe ngokuqinileyo. S4 - Gcina kude neendawo zokuhlala. |
| WGK eJamani | 3 |
| Ikhowudi ye-HS | 2924 29 70 |
| IKlasi yeeNgozi | OKUTHUMEKAYO |
Intshayelelo
2. I-Solubility: I-Soluble kwi-solvents ye-organic efana ne-dimethyl sulfoxide (DMSO) kunye ne-ethyl acetate (EtOAc), i-insoluble emanzini.
3. ifomula yemolekyuli: C32H29NO4.
4. ubunzima bemolekyuli: 495.58.
Olona setyenziso luphambili lwe-Fmoc-L-homophenylalanine liqela elikhuselayo kwi-peptide synthesis. I-Fmoc sisishunqulelo se-furoyl kunye ne-derivatives yayo, enokukhusela iqela le-amino kwii-amino acids. Xa kufunwa ukudibanisa ikhonkco lepeptide, iqela le-amino linokwenziwa lifumaneke kwimpendulo ngokususa iqela elikhuselayo leFmoc. Ngoko ke, i-Fmoc-L-homophenylalanine idlala indima ebalulekileyo ekulungiseleleni amachiza e-peptide kunye neemolekyuli ezinxulumene ne-bioactive.
Indlela yokulungiselela i-Fmoc-L-homophenylalanine inzima kakhulu kwaye ibandakanya ukusabela kwe-multi-step synthesis. Indlela eqhelekileyo yokulungiselela i-co-reacting Fmoc-protected phenylalanine kunye nezinye ii-reagents, ezifana ne-silver azide formate (AgNO2), ilandelwa unyango lwe-trifluoroacetic acid ukunika i-Fmoc-L-homophenylalanine.
Le ngcaciso ilandelayo yokhuseleko kufuneka iqatshelwe xa usebenzisa i-Fmoc-L-homophenylalanine:
1. ugweme ukudibana ngokuthe ngqo nolusu, amehlo kunye ne-mucous membranes, kuba inokucaphukisa umzimba womntu.
2. Ukugcinwa kufuneka kugweme ukudibanisa nee-oxidants ezinamandla okanye i-acids eqinile ukukhusela ukuphendula okuyingozi.
3. Sebenzisa izixhobo ezifanelekileyo zokuzikhusela ezifana neeglavu, iiglasi zokhuselo kunye needyasi zaselabhoratri ngexesha lokusetyenziswa nokuphatha.
4. Yonke imisebenzi kufuneka yenziwe phantsi kweemeko zebhubhoratri ezinomoya opholileyo.
Isishwankathelo, i-Fmoc-L-homophenylalanine liqela elikhuselayo le-amino acid elisetyenziswa ngokuqhelekileyo kwi-peptide synthesis kwaye linoluhlu olubanzi lwezicelo. Xa usebenzisa kunye nokuphatha i-compound, kuyimfuneko ukubeka ingqalelo ekuphatheni ngokukhuselekileyo kunye nokugcinwa.
