I-L-Fmoc-Aspartic acid alpha-tert-butyl ester (CAS# 129460-09-9)
I-Fluorenylmethoxycarbonyl-aspartate-l-tert-butyl ester (Fmoc-Asp(tBu)-OH) liqela elisetyenziswa ngokuqhelekileyo elikhuselayo kwi-aspartic acid. Oku kulandelayo yinkcazo yobume bayo, ukusetyenziswa, ukuqulunqwa kunye nolwazi lokhuseleko:
Indalo:
-Ifomula yeMichiza: C26H27NO6
-Ubunzima bemolekyuli: 449.49g / mol
-Imbonakalo: Ikristale emhlophe eqinileyo
-Indawo yokunyibilika: 205-207°C
Sebenzisa:
- I-Fmoc-Asp (tBu) -OH idla ngokusetyenziswa kwi-peptide synthesis kwi-synthesis yesigaba esiqinileyo njengeqela elikhuselayo le-aspartic acid.
-Inokuvelisa amatyathanga e-peptide ngokuzisa iintsalela ze-aspartic acid kwi-synthetic peptide sequence ngokusebenzisa i-slide phase synthesis.
Indlela yokulungiselela:
- I-Fmoc-Asp (tBu) -OH inokufumaneka ngokuphendula i-isopropyl acetate okanye i-sodium hydroxide kunye ne-Fmoc-Asp (tBu) -OH.
Ulwazi ngoKhuseleko:
- I-Fmoc-Asp(tBu)-OH isetyenziswa kakhulu kushishino nakwiilabhoratri, kwaye ngokuqhelekileyo ithathwa njengento ekhuselekileyo.
-kodwa kusafuneka ingqalelo ubuthi bayo kunye nokucaphuka.
-Xa uyiphatha, nxiba izixhobo ezifanelekileyo zokukhusela, ezinjengeeglavu kunye nezibuko, ukuthintela ukudibana nolusu okanye amehlo.
-Xa ugcina kunye nokuphatha, kucetyiswa ukuba uyigcine kwindawo eyomileyo, epholileyo, kude nomlilo kunye ne-oxidizing agents.
Nceda uqaphele ukuba ukhuseleko lweekhemikhali kufuneka luphathwe ngononophelo. Uvavanyo kufuneka lwenziwe ngokuhambelana nezikhokelo zokusebenza ezikhuselekileyo kunye nokulahlwa kwenkunkuma ngokuhambelana nemimiselo efanelekileyo.
