L-Pyroglutamic acid CAS 98-79-3
Umngcipheko kunye noKhuseleko
| Iimpawu ezinobungozi | Xi – Irritant |
| Iikhowudi zoMngcipheko | 36/37/38 – Ukucaphukisa amehlo, inkqubo yokuphefumula kunye nolusu. |
| Inkcazelo yoKhuseleko | S26 – Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango. S36 – Nxiba iimpahla ezifanelekileyo ezikhuselayo. I-S37/39 -Nxiba iiglavu ezifanelekileyo kunye nokukhusela amehlo / ubuso |
| WGK eJamani | 3 |
| RTECS | TW3710000 |
| FLUKA BRAND F IIKHOWUDI | 21 |
| I-TSCA | Ewe |
| Ikhowudi ye-HS | 29337900 |
| Intshayelelo | i-pyroglutamic acid yi-5-oxyproline. Yenziwe ngokuncipha kwamanzi phakathi kweqela le-α-NH2 kunye ne-γ-hydroxyl iqela le-glutamic acid ukwenza i-molecular lactam bond; Inokusekwa ngokulahlekelwa kweqela le-Amido kwi-molecule ye-glutamine. Ukuba ukusilela kwe-glutathione synthetase, kunokubangela i-pyroglutamemia, uthotho lweempawu zeklinikhi. I-Pyroglutamemia luphazamiseko lwe-organic acid metabolism olubangelwa kukunqongophala kwe-glutathione synthetase. Ukubonakaliswa kweklinikhi yokuzalwa kwe-12 ~ 24 iiyure zokuqala, i-hemolysis eqhubekayo, i-jaundice, i-Metabolic Acidosis engapheliyo, ukuphazamiseka kwengqondo, njl.; Umchamo uqukethe i-pyroglutamic acid, i-lactic acid, i-Alpha deoxy4 glycoloacetic acid lipid. Unyango, uphawu, nikela ingqalelo ukulungelelanisa ukutya emva kweminyaka yobudala. |
| iipropati | I-L-pyroglutamic acid, eyaziwa ngokuba yi-L-pyroglutamic acid, i-L-pyroglutamic acid. Ukusuka kumxube we-ethanol kunye ne-petroleum ether kwimvula ye-orthorhombic cone ephindwe kabini yeCrystal engenambala, indawo yokunyibilika ye-162 ~ 163 ℃. Inyibilika emanzini, utywala, i-acetone kunye ne-acetic acid, i-ethyl acetate-soluble, i-ether enganyibilikiyo. Ukujikeleza okuthe ngqo kwe-optical -11.9 °(c = 2,H2O). |
| Iimpawu kunye nokusetyenziswa | kwesikhumba somntu iqulethe umsebenzi othambisayo wezinto ezinyibilikayo zamanzi-zendalo yokuthambisa, ukubunjwa kwayo kuqikelelwa ukuba i-amino acid (iqulethe i-40%), i-pyroglutamic acid (equlethe i-12%), iityuwa ezingaphiliyo (Na, K, Ca, Mg, njl. equlethe i-18.5%), kunye nezinye izinto eziphilayo (eziqulethe i-29.5%). Ke ngoko, i-pyroglutamic acid yenye yezona zinto ziphambili zolusu lwendalo yokuthambisa, kwaye amandla ayo okuthambisa adlula le glycerol kunye nepropylene glycol. Kwaye okungeyotyhefu, akukho vuselelo, luKhathalelo loLusu lwangoku, izithambiso zoLondolozo lweNwele zigqwesileyo zezinto ezikrwada. I-Pyroglutamic acid nayo inefuthe elithintelayo kumsebenzi we-tyrosine oxidase, ngaloo ndlela ikhusela ukubekwa kwezinto "ze-melanoid" esikhumbeni, enefuthe elimhlophe esikhumbeni. Inomphumela wokuthambisa eluswini, ingasetyenziselwa izithambiso zezikhonkwane. Ukongeza kwisicelo kwi-cosmetics, i-L-pyroglutamic acid inokuvelisa i-derivatives kunye nezinye izinto eziphilayo, ezineempembelelo ezikhethekileyo kumsebenzi ongaphezulu, obala kunye nokukhanya okukhanyayo, njl njl. Inokusetyenziswa njenge-surfactant ye-detergents; Ii-reagents zeMichiza zokusombulula ii-amines zobuhlanga; Izinto eziphilayo. |
| indlela yokulungiselela | I-L-pyroglutamic acid yenziwe ngokususa umzuzu omnye wamanzi kwi-molecule ye-L-glutamic acid, kunye nenkqubo yokulungiswa kwayo ilula, amanyathelo abalulekileyo kukulawula ukushisa kunye nexesha lokuchithwa kwamanzi. (1) I-500g ye-asidi ye-L-glutamic yongezwa kwi-beaker eyi-100 ml, kwaye i-beaker yafudunyezwa ngebhafu yeoli, kwaye iqondo lobushushu lanyuswa ukuya kwi-145 ukuya kwi-150 ° C. ukusabela. Unyibiliko ophelelwe ngamanzi nguTan. (2) emva kokugqitywa kwe-reaction dehydration, isisombululo sathululelwa emanzini abilayo kunye nomthamo malunga ne-350, kwaye isisombululo sachithwa ngokupheleleyo emanzini. Emva kokupholisa ukuya kwi-40 ukuya kwi-50 ° C., isixa esifanelekileyo sekhabhoni esebenzayo yongezwa ukuze kuguqulwe umbala (ngokuphindaphindiweyo kabini). Kwafunyanwa isisombululo esingenambala esicacileyo. 3 kwaye kwindawo yokuhlambela yamanzi ashushu ukucothisa icrystallization, iiyure ezili-10 ukuya kwezingama-20 emva kokulungiswa kweekristale zeprismatic ezingenambala. Ubungakanani be-L-pyroglutamic acid kwi-cosmetics buxhomekeke ekubunjweni. Le mveliso ingasetyenziselwa izimonyo ngendlela ye-50% yesisombululo esigxininisiweyo. |
| i-glutamic acid | i-glutamic acid yi-amino acid eyenza iprotheni, ine-ionized acidic side chain, kwaye ibonisa i-hydrotropism. I-asidi ye-Glutamic ichaphazeleka kwi-cyclization kwi-pyrrolidone carboxylic acid, oko kukuthi, i-pyroglutamic acid. i-glutamic acid iphezulu kakhulu kuzo zonke iiproteni ze-cereal, ibonelela nge-alpha-ketoglutarate ngomjikelo we-tricarboxylic acid. I-Alpha ketoglutaric acid inokwenziwa ngokuthe ngqo kwi-ammonia phantsi kwe-catalysis ye-glutamate dehydrogenase kunye ne-NADPH (coenzyme II), kwaye inokuthi ifakwe kwi-aspartate aminotransferase okanye i-alanine aminotransferase, i-glutamic acid iveliswa yi-transamination ye-aspartic acid okanye i-alanine; Ukongezelela, i-asidi ye-glutamic inokuguqulwa ngokuphindaphindiweyo kunye neproline kunye ne-ornithine (ukusuka kwi-arginine), ngokulandelanayo. I-Glutamate ke ngoko isondlo esingabalulekanga se-amino acid. Xa i-glutamic acid ichithwa phantsi kwe-catalysis ye-glutamate dehydrogenase kunye ne-NAD (coenzyme I) okanye idluliselwe ngaphandle kweqela le-amino phantsi kwe-catalysis ye-aspartate aminotransferase okanye i-alanine aminotransferase ukuvelisa i-alpha ketoglutarate, ingena kumjikelezo we-tricarboxylic acid kwaye ivelise iswekile ngokusebenzisa indlela yegluconeogenic, ngoko i-glutamic acid ibalulekile i-amino acid ye-glycogenic. i-glutamic acid kwizihlunu ezahlukeneyo (ezifana nezihlunu, isibindi, ingqondo, njl.njl.) inokudibanisa i-glutamine kunye ne-NH3 ngokusebenzisa i-glutamine synthetase, yimveliso yokukhupha i-ammonia, ngakumbi kwizicubu zobuchopho, kunye nokugcinwa kunye nokusetyenziswa kwendlela. ammonia emzimbeni (jonga "i-glutamine kunye ne-metabolism yayo"). i-glutamic acid idityaniswe ne-acetyl-CoA njenge-cofactor ye-mitochondrial carbamoyl phosphate synthase (ebandakanyeka kwi-synthesis ye-urea) ngokusebenzisa i-catalysis ye-acetyl-glutamate synthase. I-γ-aminobutyric acid (GABA) yimveliso ye-decarboxylation ye-glutamic acid, ngakumbi ekugxininiseni okuphezulu kwizicubu zobuchopho, kwaye ibonakala egazini, umsebenzi wayo we-physiological uthathwa njenge-neurotransmitter evimbelayo, i-antispasmodic kunye ne-hypnotic effects eyenziwa Ukunyuswa kweklinikhi ye-echinocandin kunokufezekiswa nge-GABA. I-catabolism ye-GABA ingena kumjikelezo we-tricarboxylic acid ngokuguqula i-GABA transaminase kunye ne-aldehyde dehydrogenase kwi-succinic acid ukwenza i-GABA shunt. |
| Sebenzisa | isetyenziswe njengeziphakathi kwi-organic synthesis, izongezo zokutya, njl. esetyenziswa ekutyeni, kumayeza, kwizinto zokuthambisa nakwamanye amashishini |
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