Lacosamide (CAS# 175481-36-4)
Umngcipheko kunye noKhuseleko
| Iikhowudi zoMngcipheko | I-R11 – Iyatsha kakhulu I-R20/21/22 – Iyingozi ngokuphefumla, xa udibana nolusu naxa uginyiwe. R36 – Iyandicaphukisa emehlweni |
| Inkcazelo yoKhuseleko | S16 – Gcina kude kwimithombo yomlilo. S26 – Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango. S36/37 – Nxiba iimpahla ezifanelekileyo zokukhusela kunye neeglavu. |
| Izazisi ze-UN | UN 1648 3 / PGII |
| WGK eJamani | 2 |
| Ikhowudi ye-HS | 2924296000 |
I-Lacosamide (CAS # 175481-36-4) isingeniso
I-Lactamide yiklasi yeekhompawundi eziphilayo eziqulethe i-lactam rings. Oku kulandelayo kukwazisa kwiipropati, ukusetyenziswa, iindlela zokulungiselela kunye nolwazi lokhuseleko lwe-laclamide:
Umgangatho:
Iimpawu ze-laclamide zixhomekeke kwisakhiwo sayo se-molecular kunye nobukhulu bendandatho. Ngokubanzi, i-lacamide yikristale emhlophe eqinileyo kunye nokuzinza okuqinileyo. Inonyibiliko olulungileyo, lunyibilika kwizinyibilikisi zendalo ezifana ne-ethers kunye neeketones, kwaye azinyibiliki emanzini.
Sebenzisa:
I-Laccamide inoluhlu olubanzi lwezicelo kwishishini lemichiza. Eyona nto ibalulekileyo kwezi kukusetyenziswa kwayo njengesandulela kwizinto zepolymer. Umzekelo, iifiber zepolyamide (nylon) zenziwe ngepolymerizing laclamide. I-laxamide isenokusetyenziswa njengesiphakathi kwizinyibilikisi, izinto ezincedayo, nanjengemathiriyeli ekrwada yokwenza iintsinga zokwenziwa, irabha yokwenziwa, amayeza kunye nedayi.
Indlela:
Ngokubanzi, i-synthesis ye-laxamide iphunyezwa ikakhulu nge-acid-catalyzed cyclization. Ngokukodwa, iindlela zokulungiselela ezisetyenziswa ngokuqhelekileyo zezi zilandelayo:
Indlela ye-pamine: isebenzisa i-amines kunye ne-acid chloride okanye i-anhydride ukusabela phantsi kweemeko ezifanelekileyo ukuvelisa i-laxamide.
Iindlela ze-asidi ezingezizo zakudala: Umzekelo, emva kokuba i-medium kwi-catalytic reactor iphiliswe ngokupheleleyo, i-ferric chloride kunye ne-acid catalyst inokuguqulwa ibe yi-laclamide kumaqondo aphantsi.
Indlela yokusabela ngoxinzelelo oluphezulu: I-Laclamine yenziwe ngesixhobo se-imimine kunye ne-NBS kwindawo yoxinzelelo oluphezulu.
Ulwazi ngoKhuseleko:
ILaxamide yikhemikhali kwaye kufuneka igcinwe ngokufanelekileyo kwindawo eyomileyo, epholileyo, kude nemithombo yomlilo kunye nee-oxidants.
Ngexesha lokusebenza, iimeko zokungena komoya ezifanelekileyo kufuneka zigcinwe kwaye izixhobo ezifanelekileyo zokuzikhusela ezifana neeglavu zokhuselo, izikhuselo zobuso, kunye nempahla yamehlo ekhuselayo kufuneka isetyenziswe.
I-Laclamide inokucaphukisa ulusu kunye namehlo.
Xa ulahla inkunkuma, kufuneka ilahlwe ngendlela efanelekileyo ngokuhambelana nemimiselo yendawo.
