Methyl 2-cyanoisonicotinate (CAS# 94413-64-6)
Umngcipheko kunye noKhuseleko
| IKlasi yeeNgozi | 6.1 |
Indlela yokuvelisa
i-compound ekujoliswe kuyo yalungiswa nge-oxidation, i-amidation kunye ne-dehydration kunye ne-methyl 2-methyl 4-pyridinecarboxylate (2) njengento yokuqala. ubume bayo buqinisekiswe yi-1H NMR kunye ne-MS, kwaye isivuno sisonke sasiyi-53.0%. Iimpembelelo zomlinganiselo wokutya, ubushushu bekristalllization, ixesha lokuphendula kunye nezinye izinto kwimveliso zafundwa ngovavanyo lwento enye, kwaye iimeko zenkqubo zaphuculwa: n (2): n (potassium permanganate) = 1.0: 2.5, ukushisa kwecrystallization 0 ~5 ℃;n (methyl 2-carboxyl -4-pyridinecarboxylate):n (sulfoxide) = 1.0:1.4, ukuphendula; impendulo yokuphelelwa ngamanzi emzimbeni ikhetha inkqubo ye-trifluoroacetic anhydride-triethylamine njenge-agent ekhupha amanzi. Inkqubo ilula ukusebenza, iimeko zokusabela zilula, kulula ukunyusa imveliso, kwaye inexabiso elifanelekileyo lesicelo.
Sebenzisa
I-Tobisostat isetyenziselwa ukunyanga i-hyperuricemia engapheliyo yegout. Xa kuthelekiswa neyeza lesintu i-allopurinol (i-analog ye-purine), ayiyi kuchaphazela i-purine kunye ne-pyridine metabolism kunye nomsebenzi we-enzyme, kwaye iyanciphisa i-uric acid Isiphumo sinamandla, akukho lawulo oluphindaphindiweyo olufunekayo, kwaye ukhuseleko lungcono. I-Methyl 2-cyano-4-pyridine carboxylate yinto ebalulekileyo ekrwada kwi-synthesis yeTobiso.
