I-Metomidate (CAS# 5377-20-8)

Intshayelelo

Oku kulandelayo kukwazisa ngobume, ukusetyenziswa, indlela yokuvelisa, kunye nolwazi lokhuseleko lweMetomidate:

Umgangatho:

1. Imbonakalo: Uhlobo oluqhelekileyo lweMetomidate luqina olumhlophe.

2. Ukunyibilika: Ine-solubility ephantsi emanzini kwaye iyanyibilika kwii-solvents eziphilayo ezifana ne-methanol kunye ne-ethanol.

Sebenzisa:

I-Metomidate isoloko isetyenziswa njenge-anesthetic yezilwanyana kunye ne-hypnotic agent. I-GABA receptor agonist eyenza ukuzola kunye nefuthe le-hypnotic ngokuchaphazela iindlela ezithile kwinkqubo ye-nervous central. Kwiyeza lezilwanyana, lisetyenziswa ngokuqhelekileyo kwi-anesthesia kwiintlanzi, i-amphibians, kunye nezilwanyana ezirhubuluzayo.

Indlela:

Ukulungiswa kweMetomidate ngokuqhelekileyo kubandakanya la manyathelo alandelayo:

1. I-3-cyanophenol kunye ne-2-methyl-2-propanone i-condensed ukuze yenze i-intermediate.

2. I-intermediate iphendulwa nge-formaldehyde phantsi kweemeko ze-alkaline ukwenza i-precursor ye-Metomidate.

3. Ukufudumeza kunye ne-hydrolysis ye-precursor phantsi kweemeko ze-alkali ukuvelisa imveliso yokugqibela ye-Metomidate.

Indlela ethile yokudibanisa inokuhlengahlengiswa ngokwenkqubo ethile kunye neemeko.

Ulwazi ngoKhuseleko:

1. I-Metomidate yi-anesthetic kwaye kufuneka isetyenziswe ngokuhambelana nemigaqo yokhuseleko efanelekileyo.

3. Inokuba nefuthe kwinkqubo ye-nervous central, ngoko ke kufuneka kuqwalaselwe ngenyameko xa usebenzisa ukuphepha ukusetyenziswa ngokugqithiseleyo.

4. I-Metomidate yinto eyityhefu kwaye iinkqubo ezifanelekileyo zokulawula imichiza kufuneka zilandelwe ngexesha lokugcinwa nokuphathwa.