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Mitotan (CAS# 53-19-0) Umfanekiso okhoyo
  • Mitotan(CAS# 53-19-0) 1

Mitotan (CAS# 53-19-0)

Ipropati yeMichiza:

Ifomula yeemolekyuli C14H10Cl4
IMisa yeMolar 320.04
Ukuxinana 1.3118 (uqikelelo olurhabaxa)
Indawo yokunyibilika 77-78°C(lit.)
Indawo yeBoling 405.59°C (uqikelelo olurhabaxa)
Ukunyibilika kwamanzi <0.1 g/100 mL ku-24 ºC
Ukunyibilika I-DMSO: i-soluble20mg / mL, icacile
Imbonakalo umgubo
Umbala mhlophe ukuya beige
Merck 13,6237 / 13,6237
I-BRN 2056007
Imeko yoGcino Umoya ophantsi, uBubushushu beGumbi
Refractive Index 1.6000 (uqikelelo)
IiPropati zoMzimba kunye nezeMichiza Indawo yokunyibilika ngama-76-78°C
Ukunyibilika kwamanzi <0.1g/100 mL ku-24°C
Sebenzisa Le mveliso yeyophando lwenzululwazi kuphela kwaye ayisayi kusetyenziselwa ezinye iinjongo.
Isifundo se-in vitro Kwi-mouse ye-TalphaT1 ye-cell line, i-Mitotane inqanda ukubonakaliswa kunye nokugcinwa kwe-TSH, ivimba impendulo ye-TSH kwi-TRH, kwaye iyanciphisa ukusebenza kweeseli, kwaye ibangela i-apoptosis. Kwi-pituitary TSH-secreting mouse cell, i-Mitotane ayiphazamisi i-hormone ye-thyroid, kodwa iyanciphisa ngokuthe ngqo umsebenzi we-secretory kunye nokusebenza kweeseli. I-Mitotane ibangela i-adrenal cortical necrosis, umonakalo we-membrane ye-mitochondrial, kunye nokubophelela ngokungenakuguqulwa kwiprotheni ye-CYP. I-Mitotane (i-10-40 μm) inqanda i-basal kunye ne-cAMP-induced cortisol secretion kodwa ayizange ibangele ukufa kweeseli. I-Mitotane ibonise imiphumo yokuthintela kwi-basal Star kunye neeprotheni ze-P450scc. I-Mitotane (40 μm) yanciphisa kakhulu amanqanaba e-mRNA ye-Star, CYP11A1 kunye ne-cyp21. I-Mitotane (40 μm) iphantse ingathathi hlangothi ngokupheleleyo ukungeniswa kwe-STAR, CYP11A1, CYP17, kunye ne-CYP21 mRNA nge-adenosine 8-bromo-cyclic phosphate. Kwinqanaba le-S leeseli ze-H295R, ukudibanisa kweMitotane kunye ne-gemcitabine kubonise ukuchasana kunye nokuphazamiseka kwe-gemcitabine-mediated inhibition kwi-cell cycle.
Kwisifundo se-vivo Kwiigundane, i-Mitotane (60 mg / kg) yanciphisa kakhulu i-adrenal mitochondrial kunye ne-microsomal "P-450" kunye ne-microsomal proteins nge-34%,55% kunye ne-35%.

Iinkcukacha zeMveliso

Iithegi zeMveliso

Iimpawu ezinobungozi Xn – Iyingozi
Iikhowudi zoMngcipheko I-40 - Ubungqina obuncinci besiphumo se-carcinogenic
Inkcazelo yoKhuseleko I-36/37 -Nxiba iimpahla ezifanelekileyo zokukhusela kunye neeglavu.
Izazisi ze-UN 3249
WGK eJamani 3
RTECS KH7880000
Ikhowudi ye-HS 2903990002
IKlasi yeeNgozi 6.1(b)
Iqela lokuPakisha III

 

Intshayelelo

I-Mitotane yi-organic compound enegama lekhemikhali N,N'-methylene diphenylamine. Oku kulandelayo sintshayelelo kwiipropati, ukusetyenziswa, iindlela zokulungiselela kunye nolwazi lokhuseleko lwe-mitotane:

 

Umgangatho:

- I-Mitotane yinto eqinileyo yekristale engenambala enyibilikayo kwizinyibilikisi zendalo ezifana ne-ethanol, i-ether, kunye nekloroform.

- IMitotane inevumba elibukhali elibukhali.

 

Sebenzisa:

- I-Mitotane isetyenziselwa ukudibanisa ukuphendula kwi-organic synthesis kwaye isoloko isetyenziswa njenge-reagent kunye ne-catalyst.

- Ingathatha inxaxheba kwiintlobo ezahlukeneyo zeekhemikhali, ezifana nokudityaniswa kwe-alkynes, i-alkylation ye-aromatics compounds, njl.

 

Indlela:

- I-Mitotane inokudityaniswa ngokusabela kwamanyathelo amabini. I-formaldehyde iphendulwa kunye ne-diphenylamine phantsi kweemeko ze-alkaline ukwenza i-N-formaldehyde diphenylamine. Emva koko, nge-pyrolysis okanye i-oxidation reaction elawulwayo, iguqulwa ibe yi-mitotane.

 

Ulwazi ngoKhuseleko:

- I-Mitotane yi-compound ecasulayo kwaye akufanele idibane ngqo nolusu kunye namehlo. Izixhobo ezifanelekileyo zokukhusela ezinjengeeglavu, iiglasi kunye nempahla yokukhusela kufuneka zinxitywe xa usebenza.

- Xa ugcina kwaye uphatha, qaphela ukutywina kunye nokukhusela ekukhanyeni ukuphepha ukudibanisa nomoya kunye nomswakama.

- I-Mitotane ibola kwiqondo lokushisa eliphezulu ukuvelisa iigesi ezinobuthi, ukuphepha ukufudumala okanye ukudibanisa nezinye izinto ezinokutsha.

- Jonga kwimimiselo yendawo kwaye ulandele iinkqubo ezifanelekileyo zokusebenza zokhuseleko xa uzilahla.

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