N-Boc-N'-tosyl-D-histidine (CAS# 69541-68-0)
Intshayelelo
I-Boc-D-His(Tos)-OH(Boc-D-His(Tos)-OH) yinto yekhemikhali enezi mpawu zilandelayo:
Indalo:
1. Imbonakalo: emhlophe eqinileyo
2. ifomula yemolekyuli: C21H25N3O6S
3. ubunzima bemolekyuli: 443.51
4. Indawo yokunyibilika: malunga ne-110-115 ° C
Sebenzisa:
I-Boc-D-His (Tos) -OH isetyenziswa ngokuqhelekileyo kwi-organic synthesis njengeqela elikhuselayo le-D-histidine (D-His). Usetyenziso lwayo oluphambili lubandakanya:
1. Kwi-synthesis ye-polypeptide, isetyenziselwa ukudibanisa ukulandelelana kwe-polypeptide equkethe iqela elikhuselayo le-D-histidine.
2. Isetyenziswe njengendawo ephakathi kwintsimi yekhemistri yonyango ukwenzela ukuhlanganiswa kweekhompawundi ezijoliswe kwi-biologically.
3. Uyilo kunye nokuhlanganiswa kweekhompawundi zabaviwa beziyobisi kuphando.
Indlela yokulungiselela:
Ukulungiswa kwe-Boc-D-His(Tos)-OH idla ngokuqhutywa ngala manyathelo alandelayo:
1. I-D-histidine (D-His) yaphendulwa nge-p-toluenesulfonyl chloride (p-toluenesulfonyl chloride) ukunika i-D-histidine p-toluenesulfonyl (D-His-Tos).
2. Ngaphantsi kweemeko ze-alkaline, i-D-His-Tos iphendulwa nge-n-butoxycarbonylhydrazine (tert-butyloxycarbonylhydrazide) ukuvelisa i-Boc-D-His (Tos) -OH.
Ulwazi ngoKhuseleko:
Uvandlakanyo lokhuseleko lwe-Boc-D-His(Tos)-OH lulinganiselwe, kodwa njengento yekhemikhali, le ngqwalasela yokhuseleko ilandelayo kufuneka iqatshelwe:
1. Kuphephe ukuphefumla, ukudibana nesikhumba kunye namehlo. Nxiba izixhobo ezifanelekileyo zokuzikhusela, ezinjengeeglavu neendondo.
2. Iindlela ezifanelekileyo zelabhoratri kufuneka zilandelwe ngexesha lokusetyenziswa kunye neemeko ezifanelekileyo zokungenisa umoya kufuneka ziqinisekiswe.
3. Gcina kwisitya esivaliweyo, kude nomlilo kunye ne-oxidant.
4. Landela imigaqo efanelekileyo kunye nezikhokelo ngexesha lokucubungula.
Xa usebenzisa i-Boc-D-His(Tos)-OH, nceda uqiniseke ukuba ulandela imimiselo yokhuseleko lwaselabhoratri efanelekileyo kunye nemiyalelo yokusebenza, kwaye ugcine kakuhle kwaye uphathe imichiza. Ukuba kuyimfuneko, kucetyiswa ukuba usebenze phantsi kwesikhokelo seengcali.
