N-Cbz-D-Tryptophan(CAS# 2279-15-4)

Intshayelelo

N (^ a) -Benzyloxycarbonyl-D-tryptophan (N (^ a) -Benzyloxycarbonyl-D-tryptophan) yikhemikhali, eyaziwa ngokuba yi-CBZ-D-Trp. Oku kulandelayo yinkcazo yobume bayo, ukusetyenziswa, ukuqulunqwa kunye nolwazi lokhuseleko:

Indalo:

N(^ a) -Benzyloxycarbonyl-D-tryptophan yikristale emhlophe ukuya kumthubi. Izinzile kwiqondo lobushushu begumbi kwaye inokugcinwa ixesha elide phantsi kweemeko ezingenamanzi. Ayinyibiliki emanzini, kodwa inyibilika kwezinye izinyibilikisi eziphilayo ezifana ne-methanol kunye ne-dimethyl sulfoxide.

Sebenzisa:

I-N (^ a) -Benzyloxycarbonyl-D-tryptophan isoloko isetyenziswa njengamaqela akhuselayo kwi-organic synthesis, ngakumbi kwi-chemical peptide synthesis. Ukusetyenziswa kwayo okuphambili njengento ephuma kwi-amino acids yokwenziwa kweemodyuli ezithile kwi-polypeptide okanye i-protein chain. Inokudlala indima ebalulekileyo ekudityanisweni kwamachiza amatsha ngolu hlobo.

Indlela:

Ukulungiswa kwe-N (^ a) -Benzyloxycarbonyl-D-tryptophan ngokuqhelekileyo iqhutyelwa yi-chemical synthesis. Okokuqala, utywala be-benzyl kunye ne-carbon dioxide basabela ukuba benze i-benzyloxycarboxylic acid, kwaye ke i-amino acid tryptophan kunye ne-benzyloxycarboxylic acid i-esterified ukufumana imveliso ye-CBZ-D-Trp. Ukusabela kufuna uncedo lwezinye izinto eziphilayo kunye nezinyibilikisi.

Ulwazi ngoKhuseleko:

I-N (^ a) -I-Benzyloxycarbonyl-D-tryptophan inolwazi oluncinane lokhuseleko, kodwa ngokusekelwe kulwazi olukhoyo, ngokuqhelekileyo ithathwa njengetyhefu. Ukuba sesichengeni kwexesha elide okanye ukuba sesichengeni ngokugqithisileyo kunokuba neziphumo ezibi kwimpilo. Ke ngoko, amanyathelo afanelekileyo okhuseleko kufuneka athathwe xa kusetyenziswa, kugcinwa kwaye kusingathwa le khompawundi, kubandakanywa ukunxiba izixhobo ezifanelekileyo zokuzikhusela kunye nokuphatha kwindawo enomoya owaneleyo. Ngexesha elifanayo, kuyimfuneko ukulandela iinkqubo ezifanelekileyo zokusebenza zokhuseleko kunye neendlela zokulahla.

Nceda uqaphele ukuba eli nqaku lishwankathelo kuphela lwekhompawundi ekuthethwa ngayo, kwaye isicelo esithile kunye novavanyo lomngcipheko kufuneka lwenziwe kwindawo ethile yebhubhoratri. Ngaphambi kokusebenzisa nayiphi na into yeekhemikhali, nceda uqiniseke ukuba ufunda ulwazi olufanelekileyo ngokweenkcukacha kwaye udibane nochwepheshe kwangaphambili.