N-Cbz-L-Leucine(CAS# 2018-66-8)
Umngcipheko kunye noKhuseleko
| Iimpawu ezinobungozi | Xn – Iyingozi |
| Iikhowudi zoMngcipheko | I-R10-Inokutsha I-R20/22 – Iyingozi ngokuphefumla kwaye ukuba iginywe. I-R37/38 – Iyacaphukisa inkqubo yokuphefumla kunye nolusu. R40 – Ubungqina obuncinane besiphumo somhlaza I-R41 – Umngcipheko womonakalo omkhulu emehlweni R36/37/38 – Ukucaphuka kwamehlo, inkqubo yokuphefumla kunye nolusu. I-R20/21/22 – Iyingozi ngokuphefumla, xa udibana nolusu naxa uginyiwe. R67 – Umphunga unokubangela ukozela kunye nesiyezi I-R63 – Ingozi enokwenzeka yokwenzakala kumntwana ongekazalwa I-R19 – Isenokwenza iiperoxide ezidubulayo |
| Inkcazelo yoKhuseleko | S16 – Gcina kude kwimithombo yomlilo. S26 – Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango. S36/37/39 – Nxiba iimpahla ezifanelekileyo zokukhusela, iiglavu kunye nokukhusela amehlo/ubuso. S45 - Kwimeko yengozi okanye ukuba uziva ungaphilanga, funa iingcebiso zonyango ngokukhawuleza (bonisa ileyibhile nanini na kunokwenzeka.) S36 – Nxiba iimpahla ezifanelekileyo ezikhuselayo. S36/37 – Nxiba iimpahla ezifanelekileyo zokukhusela kunye neeglavu. S60 – Esi sixhobo kunye nesingxobo saso kufuneka silahlwe njengenkunkuma eyingozi. |
| Izazisi ze-UN | UN 1993 3/PG 3 |
| WGK eJamani | 3 |
| RTECS | OH2921000 |
| Ikhowudi ye-HS | 29242990 |
N-Cbz-L-Leucine (CAS# 2018-66-8) intshayelelo
I-Cbz-L-leucine, igama elipheleleyo le-Boc-L-leucine (i-Boc imele iqela lokukhusela i-dibutoxycarbonyl), i-amino acid derivative. Oku kulandelayo sintshayelelo kubume bayo, ukusetyenziswa, iindlela zokwenza kunye nolwazi lokhuseleko:
Umgangatho:
- Imbonakalo: Ikristale emhlophe eqinileyo
-Inyibilikayo: Inyibilika kwi-ethanol, i-dimethylformamide (DMF) kunye ne-dichloromethane
Sebenzisa:
- I-CBZ-L-Leucine liqela eliqhelekileyo lokukhusela i-amino acid elikhusela iqela le-hydroxyl ye-leucine ngexesha lokwenziwa kweepeptides ukukhusela ukuba lingaphenduli kunye nezinye i-reactants. Kwi-peptide synthesis apho iintsalela ze-leucine ezininzi kufuneka zifakwe, i-Cbz-L-leucine ingasetyenziselwa ukukhusela iqela le-hydroxyl ye-leucine kwiinkqubo ze-synthesis ezilandelayo.
- I-Leucine i-amino acid ebalulekileyo edlala indima ebalulekileyo kwisakhiwo seprotheni kunye nomsebenzi.
Indlela:
- Ukulungiswa kwe-Cbz-L-leucine ngokuqhelekileyo kufunyenwe ngokusabela kwe-leucine kunye ne-Boc-OSu (i-Boc-N-nitrocarbonyl-L-leucine). Ekuphenduleni, i-Boc-OSu isebenza njengentshayelelo yeqela elikhuselayo kwaye ifumana impendulo ye-esterification kunye ne-leucine ukuvelisa i-Cbz-L-leucine.
Ulwazi ngoKhuseleko:
- I-Cbz-L-leucine yikhemikhali kwaye kufuneka igcinwe ngokufanelekileyo kude nokutshisa kunye nee-oxidants.
Ngexesha lokusetyenziswa, kunqande ukuphefumla uthuli lwayo okanye ukudibana nolusu kunye namehlo.
- Landela iindlela zokhuseleko ezifanelekileyo xa uphethe kwaye ugcina, kwaye unxibe izixhobo ezifanelekileyo zokuzikhusela ezifana neeglavu zaselabhu kunye nokhuselo lwamehlo.
