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N-Cbz-L-Threonine (CAS# 19728-63-3) Umfanekiso okhoyo
  • N-Cbz-L-Threonine (CAS# 19728-63-3) 1

N-Cbz-L-Threonine (CAS# 19728-63-3)

Ipropati yeMichiza:

Ifomula yeemolekyuli C12H15NO5
IMisa yeMolar 253.25
Ukuxinana 1.2499 (uqikelelo olurhabaxa)
Indawo yokunyibilika 101-103°C(lit.)
Indawo yeBoling 396.45°C (uqikelelo olurhabaxa)
Ujikelezo oluthile(α) -4.7 º (c=4, iacetic acid)
Indawo yokuflasha 261.3°C
Ukunyibilika phantse elubala kwi Methanol
Uxinzelelo loMphunga 3.7E-11mmHg ku-25°C
Imbonakalo Umgubo wekristale omhlophe ukuya kumthubi
Umbala Mhlophe ukuya Phantse mhlophe
I-BRN 2335409
pKa 3.58±0.10(Kuqikelelwe)
Imeko yoGcino Itywinwe kwindawo eyomileyo, Gcina kwisikhenkcisi, ngaphantsi kwe -20°C
Refractive Index -4.9 ° (C=2, AcOH)
MDL MFCD00065948
Sebenzisa Isetyenziselwa i-biochemical reagents, i-peptide synthesis.

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Umngcipheko kunye noKhuseleko

Iimpawu ezinobungozi Xn – Iyingozi
Iikhowudi zoMngcipheko I-R20/21/22 – Iyingozi ngokuphefumla, xa udibana nolusu naxa uginyiwe.
R36/37/38 – Ukucaphuka kwamehlo, inkqubo yokuphefumla kunye nolusu.
Inkcazelo yoKhuseleko S22 – Musa ukuphefumla uthuli.
S24/25-Kuphephe ukudibana nolusu namehlo.
S36 – Nxiba iimpahla ezifanelekileyo ezikhuselayo.
S26 – Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango.
WGK eJamani 3
Ikhowudi ye-HS 29242990

 

 

N-Cbz-L-Threonine (CAS# 19728-63-3) Ulwazi

ukulungiselela yongeza i-50mL ye-L-Thr (30mmol) kunye nesisombululo se-Na2CO3 esahluthayo esipholileyo kwibhotile ye-250mL yokusabela, kwaye ugxobhoze kwaye unyibilike kwibhafu yomkhenkce. Ukulahla i-20mL ye-Z-OSu (39.4mmol) isisombululo se-acetone kwibhotile yokusabela; Gxuma impendulo kwi-25 ℃, TLC-UV fluorescence kunye ne-ninhydrin indlela yombala esweni inkqubo yokusabela. Emva kokuphendula, yongeza i-H2O20mL, isicatshulwa kunye ne-Et2O (30mL × 2) kwi-pH> 9, uqokelele isigaba samanzi, ulungelelanise i-pH kwi-3 ~ 4 kunye ne-1.5NHCl, i-extract nge-EtOAc (30mL × 3), udibanise isigaba sezinto eziphilayo, hlamba ngesisombululo se-NaCl esigcweleyo (25mL × 2), yomile nge-anhydrous Na2SO4, khangela ukucoceka ngo I-TLC-ultraviolet fluorescence kunye nendlela yokuphuhlisa umbala we-ninhydrin, kwaye iqhume phantsi koxinzelelo oluncitshisiweyo, i-vacuum drying ukufumana ulwelo olunamafutha atyheli i-N-benzyloxycarbonyl-L-threonine, egcinwa kwiqondo lobushushu eliphantsi.
Sebenzisa I-CBZ-L-threonine yindlela ekhuselweyo ye-N-Cbz ye-L-threonine (T405500). I-L-threonine yi-amino acid ebalulekileyo kwaye idla ngokusetyenziswa njengesondlo kunye nesongezo sokutya. Uhlobo oluguqukayo lwe-Escherichia coli luvelise izixa ezikhulu ze-L-threonine kuphando kunye neenjongo zesondlo sokutya. I-L-threonine ifumaneka ngokwendalo kwiintlanzi nakwiinkukhu kwaye idityaniswe kwezinye zeeproteni ezibalulekileyo zomzimba, ezifana ne-hemoglobin kunye ne-insulin.
Isetyenziselwa i-biochemical reagents kunye ne-peptide synthesis.

 

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