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I-N-tert-Butoxacarbonyl-O-benzyl-L-threonine (CAS# 15260-10-3) Umfanekiso okhoyo
  • I-N-tert-Butoxacarbonyl-O-benzyl-L-threonine (CAS# 15260-10-3) 1

I-N-tert-Butoxacarbonyl-O-benzyl-L-threonine (CAS# 15260-10-3)

Ipropati yeMichiza:

Ifomula yeemolekyuli C16H23NO5
IMisa yeMolar 309.36
Ukuxinana 1.152±0.06 g/cm3(Kuxelwe kwangaphambili)
Indawo yokunyibilika 80-82°C(lit.)
Indawo yeBoling 461.5±45.0 °C(Kuqikelelwe)
Ujikelezo oluthile(α) 22 º (c=2 kuma-95% ethanol)
Indawo yokuflasha 187.9°C
Uxinzelelo loMphunga 1.36E-07mmHg ku-25°C
Imbonakalo Umgubo wekristale omhlophe ukuya kumhlophe
Umbala Mhlophe ukuya Phantse mhlophe
I-BRN 3065591
pKa 3.50±0.10(Kuqikelelwe)
Imeko yoGcino Gcina kwindawo emnyama, itywinwe kwindawo eyomileyo, ubushushu beGumbi
Refractive Index 16.5 ° (C=1, MeOH)

Iinkcukacha zeMveliso

Iithegi zeMveliso

Intshayelelo
I-N-Boc-O-benzyl-L-threonine yi-organic compound. Oku kulandelayo kukwazisa ngobume bayo, ukusetyenziswa, indlela yokuvelisa kunye nolwazi lokhuseleko:

Umgangatho:
I-N-Boc-O-benzyl-L-threonine i-crystalline emhlophe okanye emhlophe eqinileyo, i-soluble kwii-solvents eziqhelekileyo ezifana ne-ethanol, i-dimethylformamide, i-chloroform, njl.

Sebenzisa:
I-N-Boc-O-benzyl-L-threonine yinto ebalulekileyo ephakathi kwi-organic synthesis kwaye isetyenziswa ngokuqhelekileyo kwi-synthesis ye-peptides kunye neeprotheni. Ingasetyenziselwa njengeqela elikhuselayo kwi-slid-phase synthesis, i-liquid-phase synthesis kunye ne-ethanolamine-mediated synthesis ukukhusela ukuphendulwa kwecala le-threonine kwinkqubo yokuphendula, ukwenzela ukuba kuphuculwe ukhetho kunye nesivuno sokuphendula.

Indlela:
Ukulungiswa kwe-N-Boc-O-benzyl-L-threonine ngokuqhelekileyo kwenziwa nge-chemical synthesis. I-Threonine i-acylated kunye ne-N-tert-butoxycarbonyl (i-Boc-O-benzyl) kunye ne-activators ezifana ne-N, N-disopropylethylamine (DIPEA) okanye i-carbodiimide (DCC) yongezwa. Emva kokusabela, i-N-Boc-O-benzyl-L-threonine yafunyanwa.

Ulwazi ngoKhuseleko:
I-N-Boc-O-benzyl-L-threonine ineprofayili ephezulu yokhuseleko, kodwa njenge-compound organic, le miqathango yokhuseleko ilandelayo kufuneka iqatshelwe: ugweme ukudibanisa nesikhumba, amehlo kunye nenkqubo yokuphefumula; Nxiba iiglavu ezikhuselayo, iiglasi, kunye nemaski xa usebenza; Ukusebenza kwilabhoratri engenamoya; Kuphephe ukudibana nee-oxidants kunye neeasidi xa ugcina. Ukuba ichukunyiswe ngempazamo okanye iphefumlwe, kufuneka ihlanjwe okanye inyangwe ngonyango kwangethuba.

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