N-(tert-Butoxycarbonyl) glycylglycine (CAS# 31972-52-8)
| Iikhowudi zoMngcipheko | I-43 - Inokubangela uvakalelo ngoqhagamshelwano lwesikhumba |
| Inkcazelo yoKhuseleko | S24/25-Kuphephe ukudibana nolusu namehlo. S36/37 – Nxiba iimpahla ezifanelekileyo zokukhusela kunye neeglavu. |
| IKlasi yeeNgozi | OKUTHUMEKAYO |
Intshayelelo
I-Boc-Gly-Gly-OH, eyaziwa ngokuba yi-Boc-Gly-Gly-OH (N-tert-butyloxycarbonyl-glycyl-glycine, i-Boc-Gly-Gly-OH ngokufutshane), yinto yekhemikhali. Oku kulandelayo yinkcazo yobume bayo, ukusetyenziswa, ukulungiswa kunye nolwazi lokhuseleko:
1. Indalo:
I-Boc-Gly-Gly-OH yinto eqinileyo emhlophe ukuya kumhlophe enendawo yokunyibilika ephezulu kunye nokunyibilika okuphantsi. Izinzile kwiqondo lobushushu begumbi, kodwa inokuthotywa phantsi kobushushu obuphezulu, ukukhanya kwelanga okanye indawo efumileyo.
2. Sebenzisa:
I-Boc-Gly-Gly-OH liqela eliqhelekileyo lokukhusela i-amino acid. Isetyenziselwa ukukhusela iqela le-amino le-glycylglycine kwi-chemical synthesis ukuphepha ukusabela kwayo kwicala kwi-chemical reaction. Ngexesha lokwenziwa kwe-polypeptide okanye iprotheni, i-Boc-Gly-Gly-OH inokongezwa njengeqela elikhuselayo kwaye emva koko isuswe phantsi kweemeko ezifanelekileyo ukuvumela ukuba i-polypeptide chain yandiswe.
3. Indlela yokulungiselela:
Ukulungiswa kwe-Boc-Gly-Gly-OH ngokuqhelekileyo kuqhutyelwa ngeendlela ze-organic synthesis. Enye indlela eqhelekileyo yokulungisa kukusabela kumaqela amabini e-hydroxyl e-glycine ngokwahlukileyo kunye ne-Boc-anhydride (i-tert-butyloxycarbonyl anhydride) ukwenza i-Boc-Gly-Gly-OH. Iimeko zokusabela kufuneka zilawulwe ngexesha lokulungiselela ukuqinisekisa isivuno kunye nokucoceka.
4. Ulwazi ngoKhuseleko:
I-Boc-Gly-Gly-OH ikhuselekile ngokwentelekiso phantsi kweemeko zelabhoratri ngokubanzi, kodwa le miba ilandelayo isafuna ukuhoywa:
-Le khompawundi inokubangela ukucaphuka kwesikhumba, amehlo kunye nephecana lokuphefumula, ngoko ke sebenzisa amanyathelo okukhusela ayimfuneko njengeiglavu zaselabhoratri kunye nezibuko xa zibonakalisiwe.
-Kuphephe ukudibana ne-oxidants okanye izinto ezinokutsha ngexesha lokusetyenziswa okanye ukugcinwa ukuze uphephe iimeko ezinobungozi ezifana nomlilo okanye ukuqhuma.
-Ukuphathwa ngokufanelekileyo kunye nokulahlwa kweekhompawundi eziseleyo kunye nenkunkuma kwibhubhoratri, ngokulandela izenzo kunye nemimiselo ekhuselekileyo yangoku.
