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INalpha-FMOC-L-Glutamine (CAS# 71989-20-3) Umfanekiso okhoyo
  • Nalpha-FMOC-L-Glutamine (CAS# 71989-20-3) 1

I-Nalpha-FMOC-L-Glutamine (CAS# 71989-20-3)

Ipropati yeMichiza:

Ifomula yeemolekyuli I-C20H20N2O5
IMisa yeMolar 368.38
Ukuxinana 1.3116 (uqikelelo olurhabaxa)
Indawo yokunyibilika 220°C (dec.)(lit.)
Indawo yeBoling 498.73°C (uqikelelo olurhabaxa)
Ujikelezo oluthile(α) -18 º (c=1,DMF)
Indawo yokuflasha 377.1°C
Ukunyibilika phantse elubala kwi-N,N-DMF
Uxinzelelo loMphunga 1.47E-20mmHg ku-25°C
Imbonakalo Umgubo omhlophe
Umbala Mhlophe ukuya Phantse mhlophe
I-BRN 4722773
pKa 3.73±0.10(Kuqikelelwe)
Imeko yoGcino 2-8°C
Refractive Index -18 ° (C=1, DMF)
MDL MFCD00037137
Sebenzisa Isetyenziselwa i-biochemical reagents, i-peptide synthesis.

Iinkcukacha zeMveliso

Iithegi zeMveliso

Iimpawu ezinobungozi Xi – Irritant
Iikhowudi zoMngcipheko 36/37/38 – Ukucaphukisa amehlo, inkqubo yokuphefumula kunye nolusu.
Inkcazelo yoKhuseleko S24/25-Kuphephe ukudibana nolusu namehlo.
S36/37/39 – Nxiba iimpahla ezifanelekileyo zokukhusela, iiglavu kunye nokukhusela amehlo/ubuso.
S27 – Khulula ngoko nangoko zonke iimpahla ezosulelekileyo.
S26 – Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango.
WGK eJamani 3
Ikhowudi ye-HS 29242990
IKlasi yeeNgozi OKUTHUMEKAYO

 

Intshayelelo

I-Fmoc-Gln-OH(Fmoc-Gln-OH) iphuma kwi-amino acid eneempawu ezilandelayo:

 

Indalo:

-Ifomula yeMichiza: C25H22N2O6

-Ubunzima bemolekyuli: 446.46g / mol

-Imbonakalo: Imhlophe okanye ikristale ephantse imhlophe okanye umgubo

-I-Solubility: I-Fmoc-Gln-OH i-soluble kwezinye i-solvents eziphilayo, ezifana ne-dimethyl sulfoxide (DMSO) okanye i-N, N-dimethylformamide (DMF).

 

Sebenzisa:

-Uphando lwe-Biochemical: I-Fmoc-Gln-OH ingasetyenziselwa njengeqela elikhuselayo kwi-synthesis yesigaba esiqinileyo se-peptide okanye iprotheni synthesis.

-Uphuhliso lweDrug: I-Fmoc-Gln-OH ingasetyenziswa njengabaphakathi kwi-synthesis yamachiza okanye i-peptides esebenzayo ye-biologically.

 

Indlela yokulungiselela:

Ulungiselelo lwe-Fmoc-Gln-OH lunokuphunyezwa ngala manyathelo alandelayo:

1. Okokuqala, i-glutamine iphendulwa nge-fluoric anhydride (Fmoc-OSu) ukufumana i-Fmoc-Gln-OH acid fluoride (Fmoc-Gln-OF).

2. Emva koko, i-Fmoc-Gln-OF iphendulwa nge-pyridine (Py) okanye i-N, N-dimethylpyrrolidone (DMAP) phantsi kweemeko ezisisiseko ukuvelisa i-Fmoc-Gln-OH.

 

Ulwazi ngoKhuseleko:

-I-Fmoc-Gln-OH ikhuselekile ngokubanzi phantsi kweemeko eziqhelekileyo zokusebenza, kodwa kuseyimfuneko ukuthobela iinkqubo zokhuseleko lwebhubhoratri.

-Kulumkele ukuthintela ukudibana nolusu, amehlo okanye imifinya, kwaye ugweme ukuphefumla okanye ukungeniswa.

-Ngexesha lokusetyenziswa, unokunxiba izixhobo ezifanelekileyo zokuzikhusela, ezinjengeeglavu zaselabhoratri, iiglasi zokhuseleko kunye nempahla yaselabhoratri.

-Xa kukho nayiphi na ingozi okanye ukungahambi kakuhle, funa uncedo lwezonyango ngexesha kwaye uzise ulwazi oluthe kratya kwiikhemikhali ukuze ubhekiselele.

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