Intsimi yamachiza iyaqhubeka nokuguquguquka, kunye neekhompawundi ezithile ezifumana ingqalelo kumandla abo onyango kunye neempawu ezizodwa zeekhemikhali. Enye yeekhompawundi, i-3-(trifluoromethyl)phenylacetic acid (CAS351-35-9), iye yatsala ingqalelo eUnited States naseSwitzerland. Eli nqaku liphonononga iintsingiselo zangoku, amandla emarike kunye nethemba lekamva lale khompawundi kwezi marike zimbini zibalulekileyo.
Isishwankathelo seMarike
I-3-(i-Trifluoromethyl) i-phenylacetic acid yi-intermediate eguquguqukayo esetyenziswa kwi-synthesis yamachiza ahlukeneyo, ngakumbi ekuphuhlisweni kweziyobisi ezichasayo kunye ne-analgesic. Iqela layo elikhethekileyo le-trifluoromethyl liphucula i-lipophilicity kunye nokuzinza kwe-metabolic yekhompawundi enesiphumo, iyenza ibe lukhetho olunomtsalane kubaphuhlisi bamachiza. I-United States ne-Switzerland, ezaziwa ngoshishino lwazo lwamayeza aqinileyo, ziphambili ekuphuhliseni ikhompawundi.
EUnited States, imarike yoxubo-mayeza iphawulwa ngamanqanaba aphezulu okuvelisa izinto ezintsha kunye notyalo-mali lophando. Ubukho beenkampani ezinkulu ezixuba amayeza kunye nenkqubo-sikhokelo yolawulo eyomeleleyo ye-FDA iququzelela uphuhliso norhwebo lwamachiza amatsha. Imfuno ye-3-(trifluoromethyl) phenylacetic acid kulindeleke ukuba inyuke njengoko iinkampani zifuna ukwenza unyango olusebenzayo oluneziphumo ebezingalindelekanga ezimbalwa.
ISwitzerland, kwelinye icala, yaziwa ngomgangatho wayo ophezulu wokuvelisa amayeza kunye nobuchule bophando. Ilizwe likhaya kwiinkampani ezininzi eziphambili zamayeza ezityala imali eninzi kuphando nophuhliso. Imarike yaseSwitzerland ihlawula ingqalelo ekhethekileyo ekuphuhliseni iyeza elichanekileyo kunye nonyango olujoliswe kuyo, apho iikhompawundi ezifana ne-3-(trifluoromethyl) phenylacetic acid zingadlala indima ebalulekileyo.
Imekobume yoLawulo
I-United States neSwitzerland zombini zinezikhokelo zolawulo ezingqongqo kwishishini loxubo-mayeza. EUnited States, i-FDA yongamela inkqubo yokuvunywa kwamachiza amatsha kwaye iqinisekisa ukuba ayahlangabezana nemigangatho yokhuseleko kunye nokusebenza kakuhle. Ngokunjalo, iSwitzerland igcina imigangatho engqongqo yokuvunywa kweziyobisi phantsi kwe-Swiss Agency for Therapeutic Goods (Swissmedic). Ezi ziphathamandla zolawulo zibalulekile ekumiseni amandla emarike ye-3-(trifluoromethyl)phenylacetic acid njengoko zinefuthe kwisantya sophando nophuhliso kunye nokuqaliswa kweemveliso ezintsha.
Imingeni yeMarike
Ngaphandle kwamathemba ayo athembisayo, imarike ye-3-(trifluoromethyl)phenylacetic acid isajongene nemingeni ethile. Umqobo obalulekileyo lixabiso eliphezulu lophando kunye nophuhliso, elinokuthi lithintele iinkampani ezincinci ekungeneni kwimarike. Ukongeza, ukuntsonkotha kokudibanisa le khompawundi kunye nokuqinisekisa umgangatho ongaguqukiyo kubangela imingeni kubavelisi.
Ukongeza, ugqaliselo olukhulayo lweshishini loxubo kwiinkqubo ezizinzileyo kunye nezokusingqongileyo zinokuchaphazela iindlela zemveliso ye-3-(trifluoromethyl)phenylacetic acid. Iinkampani ziphantsi koxinzelelo lokwamkela itekhnoloji eluhlaza, enokukhokelela ekutshintsheni kwikhonkco lokubonelela kunye neenkqubo zokuvelisa.
ithemba
Ukujonga phambili, imakethi ye-3-(trifluoromethyl) phenylacetic acid kulindeleke ukuba ikhule e-United States naseSwitzerland. Ukwanda kokuxhaphaka kwezifo ezinganyangekiyo kunye nesidingo sonyango olutsha kuqhuba imfuno yeekhompawundi zamayeza amatsha. Njengoko uphando luqhubeka nokutyhila izicelo ezinokuthi zibe kho zale khompawundi, sinokubona ukwanda kokusetyenziswa kwayo kuphuhliso lwamachiza.
Ukongeza, intsebenziswano phakathi kwamaziko emfundo kunye neenkampani ezixuba amayeza kulindeleke ukuba iphucule imeko yophando kwaye ikhokelele kwizicelo ezintsha kunye noqulunqo. Ugxininiso kumayeza omntu kunye nonyango olujoliswe kuyo luya kudala amathuba amatsha e-3-(trifluoromethyl) phenylacetic acid, okwenza kube ngumdlali ophambili kuphuhliso lwamachiza kwixesha elizayo.
Isishwankathelo, i-3-(trifluoromethyl) imarike ye-phenylacetic acid ye-pharmaceutical e-United States nase-Switzerland ikwindlela ephezulu, eqhutywa yintsha, inkxaso yolawulo, kunye nemfuno ekhulayo yezisombululo zonyango ezisebenzayo. Njengoko ishishini liqhubeka nokuvela, le khompawundi inokudlala indima ebalulekileyo ekubumbeni ikamva leyeza.
Ixesha lokuposa: Oct-30-2024