Imarike yamayeza yaseYurophu iphantsi kotshintsho olubalulekileyo, oluqhutywa yimfuno ekhulayo yonyango olutsha kunye nophuhliso oluqhubekayo lweenkqubo zokwenziwa kweziyobisi. Omnye wabadlali abaphambili kule ntsimi yi-2-aminobenzonitrile, i-pharmaceutical intermediate ebalulekileyo eye yatsala ingqalelo enkulu ngenxa yendima yayo kwi-synthesis ye-lapatinib, unyango olujoliswe kuyo olusetyenziselwa ngokukodwa ukunyanga umhlaza webele.
I-2-Aminobenzonitrile, isazisi samachiza1885-29-6, yikhompawundi enevumba elimnandi eyibhloko yokwakha ephambili ekuvelisweni kweentlobo ngeentlobo zamayeza. Iimpawu zayo ezikhethekileyo zeekhemikhali zenza ukuba kube yinto ebalulekileyo ephakathi kwi-synthesis ye-lapatinib, i-dual tyrosine kinase inhibitor ejolise kwi-epidermal growth factor receptor (EGFR) kunye ne-epidermal growth factor receptor 2 (HER2). Le ndlela yokusebenza iluncedo kakhulu kwizigulana ezinomhlaza wamabele we-HER2, ibonelela ngendlela yonyango ekujoliswe kuyo enciphisa umonakalo kwiiseli ezisempilweni xa kuthelekiswa nechemotherapy yesintu.
Kwiminyaka yakutshanje, imfuno ye-lapatinib iye yanda ngokunyuka kwezehlo zomhlaza wamabele kunye nokwandisa ulwazi ngokubaluleka kweyeza lomntu. Ngenxa yoko, imarike ye-pharmaceutical intermediates, kuquka i-2-aminobenzonitrile, ikhula ngokukhawuleza. Iinkampani zaseYurophu zonyango zityala imali eninzi kuphando kunye nophuhliso lokuphucula ukusebenza kakuhle kwemveliso ye-lapatinib, ethi iqhube imfuno yabaphakathi abakumgangatho ophezulu.
Enye yezinto eziphambili eziphembelela imarike ye-2-aminobenzonitrile yaseYurophu yindawo engqongqo yolawulo yendawo. I-Arhente ye-European Medicines Agency (EMA) ibeke izikhokelo eziqinileyo zokuvelisa kunye nokulawulwa komgangatho wabaphakathi bamayeza, ukuqinisekisa ukuba kuphela imigangatho ephezulu kakhulu. Esi sikhokelo solawulo asikhuseli kuphela ukhuseleko lwesigulane kodwa sikwakhuthaza ukutsha ngaphakathi kwishishini njengoko iinkampani zizama ukuthobela le migangatho ngelixa ziphuhlisa iindlela zokwenziwa ezintsha kunye neziphuculweyo.
Ngaphaya koko, imakethi yaseYurophu iphawulwa ngokukhula kokuthambekela kokuzinza kunye nekhemistri eluhlaza. Abavelisi bamachiza bayanda befuna iinkqubo ezihambelana nokusingqongileyo ukuvelisa i-intermediates efana ne-2-aminobenzonitrile. Olu tshintsho luqhutywa luxinzelelo lolawulo kunye nemfuno yabathengi yezenzo ezizinzileyo. Iinkampani zihlola ezinye iindlela zokudibanisa ukunciphisa inkunkuma kunye nokunciphisa impembelelo yokusingqongileyo kwimisebenzi yazo, ngokuhambelana neenjongo ezibanzi ze-European Green Deal.
Ukongeza kuzinzo, imarike yamayeza yaseYurophu ikwafumana amaza okuqhubela phambili kwetekhnoloji. Ukudityaniswa kobukrelekrele bokwenziwa (AI) kunye nokufunda koomatshini kwinkqubo yophuhliso lwamachiza kuguqula indlela abaphakathi bamayeza baveliswa ngayo. Ezi teknoloji zenza ukuba iinkampani zikwazi ukwandisa iindlela zazo zokwenziwa, ukunciphisa iindleko zemveliso, kunye nokukhawulezisa ixesha lokuthengisa amachiza abalulekileyo anjenge-lapatinib.
Njengoko imarike yaseYurophu yamayeza iqhubeka nokuphuhlisa, indima yabaphakathi njenge-2-aminobenzonitrile iya kuhlala ibalulekile. Uphando oluqhubekayo kwizicelo ezitsha kunye neendlela zokwenza izinto ezinokuthi ziqhubele phambili ukutsha kwimveliso ye-lapatinib kunye nezinye iindlela zonyango ezijoliswe kuzo. Oku ke kuya kuphucula ukhetho lonyango lwezigulane kwaye kube negalelo ekukhuleni ngokubanzi kwishishini lamayeza laseYurophu.
Ngamafutshane, ukudityaniswa kokuthotyelwa kwemithetho, ukuzinza, kunye nokutsha kwetekhnoloji kubumba ikamva lemarike yamayeza yaseYurophu. Njengoko imfuno ye-lapatinib kunye nabaphakathi bayo, njenge-2-aminobenzonitrile, iyaqhubeka nokunyuka, abachaphazelekayo kulo lonke ishishini kufuneka balungelelanise le mikhwa ukuze bahlale bekhuphisana kwaye bahlangabezane neemfuno eziguqukayo zezigulane. Ikamva lama-pharmaceutical intermediates liqhakazile, kwaye i-2-aminobenzonitrile iphambili kulo mhlaba onamandla.
Ixesha lokuposa: Dec-12-2024