Uhlalutyo lwemarike: I-3,5-di-tert-butyl-4-hydroxybenzyl alcohol (CAS 88-26-6) njengeyeza kunye neyongezelelweyo yokugqoka e-United States naseYurophu.

Ishishini loxubo-mayeza liyaqhubeka nokuvela kwaye libeka ugxininiso olwandayo kuphuhliso lweenkqubo zokuhanjiswa kwamachiza ezikumgangatho ophezulu. Enye yezinto eziphambili kule nguquko kukusetyenziswa kwezongezo ezikhethekileyo zokuphucula ukusebenza kunye nokuzinza kweendlela zokwenziwa kweziyobisi. Phakathi kwabo, i-3,5-di-tert-butyl-4-hydroxybenzyl utywala (CAS88-26-6) uye waba ngumdlali obalulekileyo, ngokukodwa kwintsimi yezongezo zokugubungela amayeza.

Iprofayili yeMichiza kunye neePropati

I-3,5-di-tert-butyl-4-hydroxybenzyl utywala yi-phenolic compound eyaziwa ngokuba yi-antioxidant properties. Ubume bayo obukhethekileyo beekhemikhali buvumela ukuba sebenze ngokufanelekileyo njenge-stabilizer kunye ne-preservative kwiintlobo ezahlukeneyo zokuqulunqa. I-compound ibonakaliswe ngokukwazi ukuvimbela ukuchithwa kwe-oxidative, okubaluleke kakhulu ekugcineni ukusebenza kunye nobomi beshelufu yeemveliso zamachiza. Le propati yenza ukuba ixabiseke kakhulu ekuqulunqweni kweengubo ezikhusela izithako ezisebenzayo zamachiza (APIs) kwizinto ezisingqongileyo ezifana nokufuma kunye nokukhanya.

Ukusetyenziswa kweemarike zamachiza

Kwicandelo lamachiza, iingubo zidlala indima ebalulekileyo kwiinkqubo zokuhanjiswa kweziyobisi. Zisetyenziselwa ukulawula ukukhutshwa kweziyobisi, ukugquma incasa engathandekiyo, kunye nokukhusela izithako ezibuthathaka ekuthotyweni. Ukongezwa kwe-3,5-di-tert-butyl-4-hydroxybenzyl yotywala kule mibhobho inika uzinzo olongezelelweyo kunye nokukhuselwa, ngaloo ndlela kuphucula ukusebenza kwabo. Ngenxa yoko, imfuno yale khompawundi iyanda, ngakumbi e-United States naseYurophu, apho imigaqo engqongqo kunye nemigangatho yomgangatho iqhuba imfuno yezongezo zokusebenza okuphezulu.

Ukuqonda kwiMarike yeNgingqi

EUnited States, imarike yoxubo-mayeza yenye yezona zinkulu ehlabathini, kugxininiswa ngamandla kubuchule obutsha kunye nomgangatho. Ukusetyenziswa kwetekhnoloji yokugquma okuphambili kuya kuxhaphaka ngakumbi, kwaye abavelisi bayanda bejonge kwizongezo ezisebenzayo ukuphucula ukwakheka kwazo. Indlela ekhulayo yamayeza omntu ngamnye kunye nophuhliso lweenkqubo zokuhanjiswa kweziyobisi ezintsonkothileyo ziqhubela phambili imfuno yezongezo ezikhethekileyo ezifana ne-3,5-di-tert-butyl-4-hydroxybenzyl alcohol.

Ngokunjalo, eYurophu, ishishini loxubo mayeza liphawulwa ngesakhelo solawulo esingqongqo esibeka phambili ukhuseleko lwesigulane kunye nokusebenza ngempumelelo kwemveliso. I-Arhente ye-European Medicines Agency (EMA) iye yaqulunqa izikhokelo zokukhuthaza ukusetyenziswa kwe-excipients ezikumgangatho ophezulu kunye nezongezelelo ekuqulunqweni kwamayeza. Ke ngoko, imakethi yokongeza i-3,5-di-tert-butyl-4-hydroxybenzyl utywala kulindeleke ukuba ibone ukukhula okubonakalayo kwiminyaka ezayo.

Ikamva elizayo

Njengesongezo sokutyabeka amayeza, amathemba ekamva le-3,5-di-tert-butyl-4-hydroxybenzyl imakethi yotywala iyathembisa. Ngophando oluqhubekayo kunye neenzame zophuhliso ezijolise ekwandiseni iinkqubo zokuhanjiswa kweziyobisi, imfuno yezinzisi ezisebenzayo kunye nezithinteli zinokunyuka. Ukongeza, ukwandisa ulwazi phakathi kwabathengi kunye nabasebenzi bezempilo ngokubaluleka komgangatho wemveliso kunye nokhuseleko kuya kuqhuba ngakumbi ukwamkelwa kwezongezo ezisebenza ngokuphezulu kuqulunqo lwamayeza.

Isishwankathelo, i-3,5-di-tert-butyl-4-hydroxybenzyl alcohol (i-CAS 88-26-6) kulindeleke ukuba idlale indima ebalulekileyo kumashishini amayeza, ngakumbi njenge-additive coating. Isakhono salo sokuphucula uzinzo kunye nokusebenza kakuhle kwemixube yoxubo lwenza ukuba ibe licandelo elibalulekileyo kuphuhliso lweenkqubo zokuhanjiswa kwamachiza ezihambele phambili. Njengoko imakethi iqhubeka nokuvela, abachaphazelekayo kushishino loxubo mayeza kufuneka bahlale bejongile kwiintsingiselo kunye nezinto ezintsha ezinxulumene nale khompawundi ukuze kunyuswe iinzuzo zayo.