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Nikorandil (CAS# 65141-46-0) Umfanekiso okhoyo
  • Nikorandil(CAS# 65141-46-0) 1

Nikorandil(CAS# 65141-46-0)

Ipropati yeMichiza:

Ifomula yeemolekyuli C8H9N3O4
IMisa yeMolar 211.17
Ukuxinana 1.4271 (uqikelelo olurhabaxa)
Indawo yokunyibilika 92°C
Indawo yeBoling 350.85°C (uqikelelo olurhabaxa)
Indawo yokuflasha 230°C
Ukunyibilika I-DMSO: > 10 mg/mL. Inyibilika kwi-methanol, ethanol, iacetone okanye iglacial acetic acid, inyibilika kancinane kwi-chloroform okanye emanzini, iphantse inganyibiliki kwi-ether okanye kwibenzene.
Uxinzelelo loMphunga 1.58E-08mmHg ku-25°C
Imbonakalo Umgubo wekristale omhlophe ukuya kumhlophe
Umbala mhlophe ukuya kumhlophe
Merck 14,6521
Imeko yoGcino 2-8°C
Refractive Index 1.7400 (uqikelelo)
MDL MFCD00186520
IiPropati zoMzimba kunye nezeMichiza Umgubo omhlophe wekristale, ongenavumba okanye onevumba elincinane, ukrakra. Inyibilika kwi-methanol, i-ethanol, i-acetone okanye i-acetic acid, inyibilika kancinane kwi-chloroform okanye emanzini, ezimbalwa azinyibiliki kwi-ether okanye kwi-benzene. Indawo yokunyibilika 88.5-93.5 °c. Ityhefu ebukhali LD50 iimpuku (mg / kg): 1200-1300 ngomlomo, 800-1000 emithanjeni.
Sebenzisa Ukuthintela isifo senhliziyo, i-angina pectoris
Isifundo se-in vitro I-Nicorandil (i-100 mM) inyuse i-flavoprotein oxidation, kodwa ayizange ichaphazele i-membrane yangoku, ibuyisela i-mitoK (ATP) kunye ne-surfaceK (ATP) iziteshi kwiindawo eziphezulu kune-10-fold. I-Nicorandil inciphisa ukufa kweseli kwimodeli ye-ischemic granulation, i-cardioprotective effect evalwe yi-mitoK (ATP) i-block blocker ye-5-hydroxydecanoic acid kodwa kungekhona nge-surfaceK (ATP). Impembelelo ye-blocker yesiteshi i-HMR1098. I-Nicorandil (i-100 mM) inqanda ukulahleka kwe-TUNEL positivity, i-cytochrome C translocation, i-caspase-3 activation, kunye ne-mitochondrial membrane potential (Delta (Psi) (m)). Uhlalutyo lweeseli ezingcoliswe yi-fluorescence Delta(Psi)(m)-indicator, i-tetramethylrhodamine ethyl ester (TMRE) nge-fluorescence isebenze isihlungi seeseli ibonise ukuba, i-nicorandil ikhusela i-Delta(Psi)(m) i-depolarization ngendlela yoxinaniso-exhomekeke (EC(50) ) malunga ne-40 mM, ukuzaliseka kwe-100 mM). Kuzo zombini iiseli ezosulelekileyo, iNicorandil isebenze ubuthathaka bokulungiswa kwangaphakathi, i-glibenclamide-sensitive 80 pS K channel. Kwiiseli ze-HEK293T, iNicorandil ivula ngokukhethekileyo isitishi se-K(ATP) esiqulethe i-SUR2B. I-Nicorandil (i-100 mM) inqande kakhulu inani leeseli kwi-TUNEL-positive nuclei kwaye yanda i-20 mM h2o2-induced caspase-3 umsebenzi. I-Nicorandil igxininise-ngokuxhomekeka ikhusela ukulahlekelwa kweDeltaPsim eyenziwa yi-H2O2.
Kwisifundo se-vivo I-Nicorandil (i-2.5 mg / kg imihla ngemihla, po) ngokudibanisa ne-Amlodipine (5.0 mg / kg imihla ngemihla, po) iintsuku ezintathu zesenzo zithintele kakhulu utshintsho kunye nokubuyisela umsebenzi we-enzyme kumanqanaba asondeleyo kulawo amagundane aqhelekileyo.

Iinkcukacha zeMveliso

Iithegi zeMveliso

Iimpawu ezinobungozi Xn – Iyingozi
Iikhowudi zoMngcipheko I-R22 – Iyingozi xa iginyiwe
I-R41 – Umngcipheko womonakalo omkhulu emehlweni
Inkcazelo yoKhuseleko S26 – Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango.
S39 –Nxiba ukhuseleko lwamehlo / ubuso.
WGK eJamani 3
RTECS US4667600
Ikhowudi ye-HS 29333990
Ubutyhefu I-LD50 kwiigundane (mg / kg): 1200-1300 ngomlomo; 800-1000 iv (Nagano)

 

Intshayelelo

I-Nicolandil, eyaziwa ngokuba yi-nicorandil amine, yi-organic compound. Oku kulandelayo sintshayelelo kwiipropati, ukusetyenziswa, ukulungiswa kunye nolwazi lokhuseleko lwe-nicorandil:

 

Umgangatho:

-INicorandil yikristale engenambala eqinileyo enyibilikayo emanzini nakwizinyibilikisi zendalo.

- Yingqungquthela ye-alkaline enokuthi isebenze kunye ne-acids ukuvelisa i-compounds yetyuwa.

- INicorandil izinzile emoyeni, kodwa inokubola xa ibonakaliswe kumaqondo aphezulu.

 

Sebenzisa:

- I-Nicolandil inokusetyenziswa kwakhona kwi-synthesis ye-organic synthesis catalysts, i-photosensitizers, njl.

 

Indlela:

- I-Nicolandil idla ngokulungiswa ngokuphendula kwe-dimethylamine kunye ne-2-carbonyl compounds.

- Ukuphendula kuqhutyelwa phantsi kweemeko ze-alkaline kwaye ukusabela kokufudumala kuqhutyelwa kwi-solvent efanelekileyo.

 

Ulwazi ngoKhuseleko:

- I-Nicorandil ikhuselekile kubantu phantsi kweemeko eziqhelekileyo.

- Nangona kunjalo, kufuneka kuthathelwe ingqalelo ukuphepha ukunxibelelana ngqo namehlo, ulusu kunye nenkqubo yokuphefumula.

- Nxiba izixhobo ezifanelekileyo zokuzikhusela (PPE) ezifana neendondo zokhuseleko, iiglavu kunye nezixhobo zokuphefumla.

- Xa usebenzisa okanye ugcina i-nicorandil, kufuneka kuthathelwe ingqalelo ukuphepha ukutshisa kunye neemeko eziphezulu zokushisa.

 

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