(S)-(-)-1 2-Diaminopropane dihydrochloride (CAS# 19777-66-3)
Umngcipheko kunye noKhuseleko
| Iikhowudi zoMngcipheko | R36/37/38 – Ukucaphuka kwamehlo, inkqubo yokuphefumla kunye nolusu. I-R23/24/25 – Ityhefu ngokuphefumla, xa udibana nesikhumba naxa uginyiwe. |
| Inkcazelo yoKhuseleko | S26 – Xa udibana namehlo, hlambulula ngokukhawuleza ngamanzi amaninzi kwaye ufune iingcebiso zonyango. S36 – Nxiba iimpahla ezifanelekileyo ezikhuselayo. S45 - Kwimeko yengozi okanye ukuba uziva ungaphilanga, funa iingcebiso zonyango ngokukhawuleza (bonisa ileyibhile nanini na kunokwenzeka.) S36/37/39 – Nxiba iimpahla ezifanelekileyo zokukhusela, iiglavu kunye nokukhusela amehlo/ubuso. |
| WGK eJamani | 3 |
| FLUKA BRAND F IIKHOWUDI | 10-21 |
| Ikhowudi ye-HS | 29212900 |
(S)-(-)-1 2-Diaminopropane dihydrochloride (CAS# 19777-66-3) Ulwazi
| Isishwankathelo | (S) - (-) -diaminopropane dihydrochloride ingasetyenziselwa njenge-pharmaceutical synthesis intermediate, njengokulungiswa kwe-Dexrazoxane, yi-enantiomer ye-dextrorotatory ye-antitumor drug razoxane. Kumachiza okukhusela intliziyo, iklinikhi yoThintelo lweziyobisi ze-anthracycline ezibangelwa yityhefu ye-cardiac kunye ne-leukemia kubantwana ngenxa ye-chemotherapy ebangelwa umonakalo wentliziyo, ngokuphindaphindiweyo njenge-adjuvant kunyango lomhlaza. |
| Sebenzisa | (S)-(-) -diaminopropane I-Dihydrochloride yi-organic intermediate, inokulungiswa ngokusabela kwe-D-(-)-tartaric acid kunye nepropylenediamine. I-diamine isetyenziswe kwi-synthesis ye-chiral imidazoline compounds |
| ukulungiselela | ukulungiswa kwe-(S)-(-)-diaminopropane dihydrochloride: yongeza i-30.0gD-(-)-tartaric acid kunye ne-8.0 ml yamanzi kunye ne-g (±) -1, i-2-propanediamine kwiflask yokusabela, igxobhoze ukunyibilika, ipholile, yongeza I-Dropwise, iqondo lokushisa liye laphakanyiswa ukuba libuyele kwi-reflux kwiiyure ze-2 ngokuvuselela. Ukuxubha kwamiswa, kwaye iqondo lokushisa liphakanyiswe kwi-80 ° C. Ngeyure eli-1. Emva koko, iqondo lobushushu laye lathotywa kancinci kancinci ukuya kwiqondo lobushushu begumbi, ukufunxa kwahluzwa, kwaye i-vacuum yomiswa ukufumana i-16.1g ye-(S) -1, 2-propanediamine ditartrate. Yongeza i-16.1g ye-(S)-1, i-2-propanediamine ditartrate kunye namanzi kwi-flask yokusabela, nyibilikise ngokufudumeza, uze wongeze isisombululo se-7.43g ye-potassium chloride kunye ne-20ml yamanzi, umxube waxutywa kwi-70 ° c. iiyure ezi-2. Emva kokupholisa, ifriji yayivunyelwa ukuba imele i-crystallization. I-filtrate yahluzwa ngokufunxa kunye ne-distilled ukuze yome phantsi koxinzelelo oluncitshisiweyo ukunika i-84% G ye-yellow solid (3), isivuno 4.02, [α] 20D = - ° (C = 1%, H2O). |
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