I-sodium nitroprusside dihydrate (CAS# 13755-38-9)

Ipropati yeMichiza:

Ifomula yeemolekyuli	I-C5H4FeN6Na2O3
IMisa yeMolar	297.95
Ukuxinana	1.72
Ukunyibilika kwamanzi	Inyibilika emanzini. I-ethanol enyibilikayo kancinane.
Ukunyibilika	Inyibilika emanzini (400 g/l) kwi-20 °C, kunye ne-ethanol (i-soluble kancinane).
Imbonakalo	Ikristale ebomvu enzulu
Ubunzima obuthile	1.72
Umbala	IRuby ebomvu
Umda wokuvezwa	I-ACGIH: TWA 1 mg/m3NIOSH: IDLH 25 mg/m3; TWA 1 mg/m3
Merck	14,8649
PH	5 (50g/l, H2O, 20℃)
Imeko yoGcino	2-8°C
Inovakalelo	Hygroscopic
MDL	MFCD00149192
IiPropati zoMzimba kunye nezeMichiza	Umgubo wekristale obomvu-mdaka, ongenavumba; Ayinancasa.
Sebenzisa	Isetyenziselwa ukumisela i-aldehydes, i-acetone, i-sulfur dioxide, i-zinc, isinyithi se-alkali, i-sulfides, njl.
Isifundo se-in vitro	I-Sodium Nitroprusside yi-vasodilator esebenzayo. I-nitroprusside ye-sodium inefuthe elisebenzayo le-vasodilatory kwi-arterioles kunye ne-venules. I-Sodium Nitroprusside iphula kwi-circulation ukukhulula i-nitric oxide (NO). I-NO isebenze i-guanylate cyclase kwi-vascular smooth muscle kwaye inyuse imveliso ye-cGMP ye-intracellular. Oku ekugqibeleni kukhokelela ekuphumleni kwe-vascular smooth muscle, evula imithambo yegazi. I-nitroprusside ye-sodium inciphisa ukwanda kwe-vascular smooth muscle.
Kwisifundo se-vivo	I-nitroprusside ye-sodium (i-5 mg / kg) njenge-nitric oxide donor yanciphisa kakhulu intestinal ischemia-reperfusion ukulimala kwiigundane.

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Umngcipheko kunye noKhuseleko

Iikhowudi zoMngcipheko	I-R25 – Inetyhefu xa iginyiwe R26/27/28 – Ityhefu kakhulu xa uphefumla, xa udibana nolusu kwaye xa uginyiwe.
Inkcazelo yoKhuseleko	S45 - Kwimeko yengozi okanye ukuba uziva ungaphilanga, funa iingcebiso zonyango ngokukhawuleza (bonisa ileyibhile nanini na kunokwenzeka.) S36/37/39 – Nxiba iimpahla ezifanelekileyo zokukhusela, iiglavu kunye nokukhusela amehlo/ubuso. S22 – Musa ukuphefumla uthuli.
Izazisi ze-UN	UN 3288 6.1/PG 3
WGK eJamani	3
RTECS	LJ8925000
FLUKA BRAND F IIKHOWUDI	3
I-TSCA	Ewe
Ikhowudi ye-HS	28372000
IKlasi yeeNgozi	6.1
Iqela lokuPakisha	III
Ubutyhefu	I-LD50 ngomlomo kuMvundla: 99 mg/kg

13755-38-9 - Isalathiso

Isalathiso

Bonisa ngakumbi

1. UTian, uYa-qin, nabanye. "Ukuthelekiswa kweendlela ezahlukeneyo zokukhupha kunye nokwenza ngcono i-extrac encediswa yi-microwave ...

13755-38-9 - Intshayelelo

Inyibilika emanzini, inyibilika kancinane etywaleni. Isisombululo sayo samanzi asizinzile kwaye sinokubola ngokuthe ngcembe kwaye sibe luhlaza.

13755-38-9 - Iinkcukacha zeNgcaciso

intshayelelo	i-nitroprusside ye-sodium (i-molecular formula: Na2[Fe(CN)5NO]· 2H2O, igama lekhemikhali: isodiyam nitroferricyanide dihydrate) yivasodilator ekhawulezayo nesebenza kancinci, esetyenziswa ngokweklinikhi kuxinzelelo lwegazi olungxamisekileyo njengengxaki yehypertension, i-hypertensive encephalopathy, Uxinzelelo lwegazi oluyingozi, i-paroxysmal hypertension ngaphambi nasemva kotyando lwepheochromocytoma, njl. njl. i-hypotension elawulwayo ngexesha lotyando lwe-anesthesia.
isiphumo	I-nitroprusside ye-sodium yi-vasodilator enamandla esebenza ngokukhawuleza, enefuthe elithe ngqo kwi-arterial kunye ne-venous smooth muscle, kwaye iyanciphisa ukuxhathisa kwe-vascular peripheral ngokuvula imithambo yegazi. Ukuhlanjululwa kwe-Vascular nako kunokunciphisa umthwalo ngaphambi nangemva kwentliziyo, ukuphucula ukuphuma kwentliziyo, kunye nokunciphisa i-reflux yegazi xa i-valve ivaliwe, ukwenzela ukuba iimpawu zokungaphumeleli kwentliziyo zinokukhululeka.
iimpawu	1. isetyenziselwa i-hypotension engxamisekileyo yeemeko eziphuthumayo, njenge-hypertension crisis, i-hypertensive encephalopathy, i-hypertension eyingozi, i-paroxysmal hypertension ngaphambi nangemva kokuhlinzwa kwe-pheochromocytoma, kwaye ingasetyenziselwa ukulawula i-hypotension ngexesha lotyando lwe-anesthesia. 2. Ngenxa yokungaphumeleli kwentliziyo, kubandakanywa i-edema ye-pulmonary edema. Ikwasetyenziselwa ukungaphumeleli kwentliziyo kwi-acute myocardial infarction okanye xa ivalve (i-mitral okanye i-aortic valve) ingavalwanga.
i-pharmacokinetics	ukufikelela kwincopho yoxinaniso lwegazi ngoko nangoko emva drip emithanjeni, kwaye inqanaba layo kuxhomekeke umthamo. Le mveliso i-metabolized ngamaseli abomvu egazi kwi-cyanide, i-cyanide kwisibindi i-metabolized ibe yi-thiocyanate, kwaye i-metabolite ayinayo umsebenzi we-vasodilating; I-cyanide inokuthatha inxaxheba kwi-metabolism ye-vitamin B12. Le mveliso isebenza ngokukhawuleza emva kokulawulwa kwaye ifikelele kwincopho yesenzo, kwaye igcina i-1 ~ 10 imizuzu emva kokuyeka ukuthontsiza kwe-intravenous. Isiqingatha sobomi bezigulane ezinomsebenzi oqhelekileyo wezintso ziintsuku ezi-7 (zilinganiswe yi-thiocyanate), ixesha elide xa umsebenzi wezintso ungalunganga okanye i-sodium yegazi iphantsi kakhulu, kwaye ikhutshwe yintso.
Inkqubo yokwenziwa yokulungiselela	sodium nitroprusside, kuquka la manyathelo alandelayo: 1) Ukwenziwa kobhedu nitroso ferrocyanide: ukongeza ubungakanani obufanelekileyo bamanzi asulungekileyo ukunyibilikisa potassium nitroso-ferricyanide kwitanki crystallization, ukufudumeza 70-80 ℃ ukuyinyibilikisa ngokupheleleyo, kwaye ngokucotha wongeza copper sulfate pentahydrate. isisombululo se-aqueous dropwise, emva kokuba impendulo igcinwe ishushu imizuzu engama-30, i-centrifuge, ikeyiki yokucoca i-centrifuged (i-nitroso ferricyanide yobhedu) yafakwa kwitanki yecrystallization. 2) I-nitroprusside ye-sodium ye-synthetic (i-sodium nitronitroferricyanide): Lungiselela isisombululo se-sodium bicarbonate egcwele amanzi ngokomlinganiselo wokutya, kwaye ngokukhawuleza uyilahle kwi-nitroso ferricyanide kwi-30-60 degrees C. Emva kokuphendula, i-centrifuge, qokelela i-filtrate kunye ne-lotion. 3) Ugxininiso kunye necrystallization: Ifiltrate eqokelelweyo kunye neloshini impontshelwa kwitanki yoxinaniso yevacuum, kunye neglacial acetic acid yongezwa kancinci kancinci de kungabikho maqamu aveliswayo. Vula ipompo yokucoca kunye nokufudumala ukuya kuma-40-60 degrees C, qalisa ukugxininiswa, ugxininise kwinani elikhulu le-crystals precipitation, vala i-valve ye-steam, i-vacuum valve ukulungiselela i-crystallization. I-4) I-Centrifugal drying: emva kwe-crystallization, i-supernatant isusiwe, i-crystals ixutywe ngokulinganayo kunye ne-centrifuged, ikhekhe lokucoca lifakwe kwi-plate yensimbi engenasici, kwaye imveliso ifunyenwe ngokumisa i-vacuum.
umsebenzi webhayoloji	I-Sodium Nitroprusside yi-vasodilator enamandla esebenza ngokukhupha ngokuzenzekelayo i-NO egazini.
Ekujoliswe kuko	Ixabiso
Sebenzisa	Isetyenziswe njenge-reagent yokuzimisela kwe-aldehydes, i-ketones, i-sulfides, i-zinc, i-sulfur dioxide, njl. Isetyenziswa njenge-reagent yokumisela i-aldehydes, i-acetone, i-sulphur dioxide, i-zinc, isinyithi se-alkali, i-sulfides, njl. Vasodilators. Ukuqinisekiswa kwe-aldehydes kunye ne-ketones, i-zinc, i-sulfur dioxide kunye ne-alkali metal sulfides. Uhlalutyo lweChromatic, uvavanyo lomchamo.