tert-butyl 2 4-dioxopiperidine-1-carboxylate (CAS# 845267-78-9)

Ifomula yeemolekyuli	C10H15NO4
IMisa yeMolar	213.23
Ukuxinana	1.199
Indawo yeBoling	373.8±35.0 °C(Kuqikelelwe)
Indawo yokuflasha	179.9°C
Uxinzelelo loMphunga	8.72E-06mmHg ku-25°C
pKa	10.67±0.20(Kuxelwe kwangaphambili)
Imeko yoGcino	Gcina kwindawo emnyama, itywinwe kwindawo eyomileyo, ubushushu beGumbi
Refractive Index	1.493
MDL	MFCD10566071

Iinkcukacha zeMveliso

Iikhowudi zoMngcipheko	I-20/21/22 – Inobungozi ngokuphefumla, xa udibana nesikhumba kwaye xa uginyiwe.
Inkcazelo yoKhuseleko	S23 – Musa ukuphefumla umphunga. S24/25-Kuphephe ukudibana nolusu namehlo.
WGK eJamani	3
Ikhowudi ye-HS	29337900

Sebenzisa	I-2, i-4-dipiperidon-1-formate tert-butyl i-formate yi-synthesis ye-phenoxymethyl-dihydrothiazolopyridone derivatives I-Reactants kwimveliso, njenge-modulator yesakhiwo esikhethiweyo (PAM) ye-metabolized glutamate 5 (mGlu5) receptor.
isicelo	I-2, i-4-dioperidone-1-tert-butyl i-formate isetyenziswa kakhulu njenge-organic intermediate kunye ne-pharmaceutical intermediate, kwaye ingasetyenziselwa uphando lwebhubhoratri kunye nenkqubo yophuhliso kunye nenkqubo ye-chemical medicine synthesis.
ukulungiselela	inyathelo a: yongeza EDCI (191.7g) kwiDMF (400mL) isisombululo 3-(tert-butoxycarbonylamino) propionic acid (189.2g,1.0mol), acid meldamic (144.1g,1.0mol) kunye DMAP (135.0g,1.1mol) ) ipholiswe yi-ice bath, 1.0mol). Ii-reactants ezibangelwayo zashukunyiswa ubusuku bonke kwiqondo lobushushu begumbi. Ukusabela kwacinywa nge-200mL H2O. Umxube obangelwayo wongezwa kwi-dropwise kwi-H2O (2.0L) phantsi kokuvuselela oomatshini. Isiqina esifunyenweyo sahluzwa kwaye sahlanjwa kakuhle ngamanzi ukuya kwi-pH 7 ukufumana imveliso (283g,90% isivuno). Inyathelo B: Isisombululo se-3-(2, 2-dimethyl-4, 6-dioxo-1, 3-dioxan-5-yl)-3-oxopropylcarbamate tert-butyl ester (100g,317.46mmol) kwi-toluene (1500mL) itshiswe kwi-100 ° C ngeeyure ezi-4. Izinto ezisabelayo ziyapholiswa kwiqondo lobushushu begumbi kwaye zigxininiswe phantsi koxinzelelo olucuthiweyo ukufumana imveliso ekrwada. Imveliso (56g,83% isivuno) yahlanjululwa yi-MTBE-grinding.